Title:
ジブチルヒドロキシトルエンの安定化方法
Document Type and Number:
Japanese Patent JP6800264
Kind Code:
B2
Abstract:
The objective of the present invention is to provide a technique for increasing the thermal stability of dibutylhydroxytoluene and suppressing a decrease in the content thereof over time in a liquid drug that includes dibutylhydroxytoluene and pranoprofen and/or a salt thereof. By mixing, into the liquid drug that includes dibutylhydroxytoluene and pranoprofen and/or a salt thereof, at least one selected from the group consisting of cromoglycic acid, allantoin, glycyrrhizinic acid, chlorpheniramine, and pharmaceutically acceptable salts of these, and by employing a resin including polybutylene terephthalate as a resin that constitutes an inner wall surface (such as the wall surface of an interior space in a spout portion and/or a lid wall surface facing a spout opening in the spout portion) of an accommodating container, the thermal stability of the dibutylhydroxytoluene in the liquid drug can be increased, adsorption of the dibutylhydroxytoluene to the container can be suppressed, and a decrease in the dibutylhydroxytoluene content over time can be suppressed.
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Inventors:
Nemoto Yukiko
Nakase Hayao
Nakase Hayao
Application Number:
JP2019071483A
Publication Date:
December 16, 2020
Filing Date:
April 03, 2019
Export Citation:
Assignee:
Senju Pharmaceutical Co., Ltd.
International Classes:
A61K31/436; A61J1/05; A61K9/08; A61K31/353; A61K31/4166; A61K31/4402; A61K31/704; A61K47/02; A61K47/10; A61P27/02; A61P29/00; A61P37/08
Domestic Patent References:
| JP6509811B2 | ||||
| JP2006232823A | ||||
| JP2005336153A | ||||
| JP2007099697A | ||||
| JP2011098960A |
Foreign References:
| WO2013009961A1 |
Attorney, Agent or Firm:
Junya Tanaka
Mizuya Kamiya
Kyoko Sakoda
Mizuya Kamiya
Kyoko Sakoda