Title:
自己免疫疾患を治療する方法
Document Type and Number:
Japanese Patent JP5541915
Kind Code:
B2
Abstract:
Methods for treating patients with autoimmune diseases are disclosed, The methods of the application include first depleting circulating lymphocytes in the mammal, e.g., by administering anti-thymocyte antibody, and then, during the course of repopulation, administering to the mammal a therapeutically effective amount of latent TGF-² and/or another agent that promotes expansion of regulatory T cells. In certain aspects, the disclosed process results in improved kidney function and survival rates.
Inventors:
Kaplan, Joan
MacPherson, John M
MacPherson, John M
Application Number:
JP2009505593A
Publication Date:
July 09, 2014
Filing Date:
April 11, 2007
Export Citation:
Assignee:
Genzyme corporation GENZYME CORPORATION
International Classes:
A61K38/00; A61K31/436; A61K31/5377; A61K31/573; A61K31/593; A61K38/21; A61K39/395; A61P37/02
Attorney, Agent or Firm:
Ono Shinjiro
Kazuo Shamoto
Kobayashi 泰
Akio Chiba
Hiroyuki Tomita
Akiko Nakahama
Kazuo Shamoto
Kobayashi 泰
Akio Chiba
Hiroyuki Tomita
Akiko Nakahama