Title:
炎症性関節疾患の治療方法
Document Type and Number:
Japanese Patent JP7066669
Kind Code:
B2
Abstract:
This invention provides compositions and methods for preventing inflammatory diseases of the joints, including rheumatoid and osteoarthritis, tendonitis, bursitis, inflammation of the ligament, synovitis, gout and systemic lupus erythematosus, wherein the methods include injecting into the inflamed joint a therapeutic anti-inflammatory composition comprising a bacterial or vial IL-10 expression construct, wherein the IL-10 expression construct comprises a bacterial or viral backbone and a nucleic acid sequence encoding interleukin-10.
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Inventors:
Chavez, Raymond A.
Watkins, Linda Earl.
Laundry, robert
Watkins, Linda Earl.
Laundry, robert
Application Number:
JP2019199475A
Publication Date:
May 13, 2022
Filing Date:
November 01, 2019
Export Citation:
Assignee:
XALUD THERAPEUTICS,INC.
THE REGENTS OF THE UNIVERSITY OF COLORADO,a body corporate
THE REGENTS OF THE UNIVERSITY OF COLORADO,a body corporate
International Classes:
A61K48/00; A61K9/50; A61K31/711; A61K38/20; A61K47/26; A61K47/34; A61P19/02; A61P19/06; A61P29/00; A61P37/02
Domestic Patent References:
| JP2008541759A |
Other References:
Dengler EC et al.,Improvement of spinal non-viral IL-10 gene delivery by D-mannose as a transgene adjuvant to control chronic neuropathic pain,Journal of Neuroinflammation,2014年05月21日,Vol.11,92,doi:10.1186/1742-2094-11-92
Milligan ED et al.,Repeated intrathecal injections of plasmid DNA encoding interleukin-10 produce prolonged reversal of neuropathic pain,Pain,2006年,Vol.126,p.294-308,doi: 10.1016/j.pain.2006.07.009
Keravala A et al.,Human, viral or mutant human IL-10 expressed after local adenovirus-mediated gene transfer are equally effective in ameliorating disease pathology in a rabbit knee model of antigen-induced arthritis,Arthritis Research & Therapy,2006年,Vol.8, No.4,R91,doi: 10.1186/ar1960
Soderquist RG et al.,Release of plasmid DNA-encoding IL-10 from PLGA microparticles facilitates long-term reversal of neuropathic pain following a single intrathecal administration,Pharmaceutical Research,2010年,Vol.27, No.5,p.841-854,doi: 10.1007/s11095-010-0077-y
Neuron Glia Biol.,2006年,Vol.2,pp.293-308
Milligan ED et al.,Repeated intrathecal injections of plasmid DNA encoding interleukin-10 produce prolonged reversal of neuropathic pain,Pain,2006年,Vol.126,p.294-308,doi: 10.1016/j.pain.2006.07.009
Keravala A et al.,Human, viral or mutant human IL-10 expressed after local adenovirus-mediated gene transfer are equally effective in ameliorating disease pathology in a rabbit knee model of antigen-induced arthritis,Arthritis Research & Therapy,2006年,Vol.8, No.4,R91,doi: 10.1186/ar1960
Soderquist RG et al.,Release of plasmid DNA-encoding IL-10 from PLGA microparticles facilitates long-term reversal of neuropathic pain following a single intrathecal administration,Pharmaceutical Research,2010年,Vol.27, No.5,p.841-854,doi: 10.1007/s11095-010-0077-y
Neuron Glia Biol.,2006年,Vol.2,pp.293-308
Attorney, Agent or Firm:
Makoto Onda
Hironobu Onda
Atsushi Honda
Nakamura Miki
Hironobu Onda
Atsushi Honda
Nakamura Miki
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