Title:
プラスマローゲン化合物、それを含有する医薬組成物及び老化による疾患を治療する方法
Document Type and Number:
Japanese Patent JP5740312
Kind Code:
B2
Abstract:
Described herein are routes of synthesis and therapeutic uses of 1-alkyl, 2-acyl glycerol derivatives of formula I: which when administered to mammalian biological systems result in increased cellular concentrations of specific sn-2 substituted ethanolamine plasmalogens independent of the ether lipid synthesis capacity of the system. Elevating levels of the specific sn-2 substituted species in this way can cause lowering of membrane cholesterol levels and the lowering of amyloid secretion. These compounds can be used for the treatment or prevention of diseases of aging associated with increased membrane cholesterol, increased amyloid, and decreased plasmalogen levels, such as neurodegeneration (including Alzheimer's disease, Parkinson's disease and age-related macular degeneration), cognitive impairment, dementia, cancer (e.g. prostate, lung, breast, ovarian, and kidney cancers), osteoporosis, bipolar disorder and vascular diseases (such as atherosclerosis, hypercholesterolemia).
Inventors:
Khan M. Amin
Wood Paul El.
Goodenoue Diane
Mankidi Rishikesh
Ahia Honu Pearson
Wood Paul El.
Goodenoue Diane
Mankidi Rishikesh
Ahia Honu Pearson
Application Number:
JP2011541046A
Publication Date:
June 24, 2015
Filing Date:
December 18, 2009
Export Citation:
Assignee:
Phenomenon Discoveries, Inc.
International Classes:
C07C229/22; A61K31/205; A61K31/385; A61P3/06; A61P9/00; A61P9/10; A61P25/00; A61P25/16; A61P25/28; A61P27/02; A61P35/00; C07C323/52; C07D339/04
Domestic Patent References:
| JP2007531706A |
Foreign References:
| WO2008093709A1 | ||||
| US20080021000 | ||||
| US4827011 |
Other References:
Arteriosclerosis, Thrombosis, and Vascular Biology,2000年,20(2),p.467-477
Tetrahedron:Asymmetry,1997年,8(18),p.3131-3142
Tetrahedron,1987年,43(16),p.3803-3816
Tetrahedron:Asymmetry,1997年,8(18),p.3131-3142
Tetrahedron,1987年,43(16),p.3803-3816
Attorney, Agent or Firm:
Masaki Hirota
Seiji Ozawa
Yusaku Tokai
Kazuhiro Matsuda
Makoto Horiuchi
Masako Yamauchi
Shohei Fujimoto
Shuichi Sonomoto
Akihiro Yamamura
Seiji Ozawa
Yusaku Tokai
Kazuhiro Matsuda
Makoto Horiuchi
Masako Yamauchi
Shohei Fujimoto
Shuichi Sonomoto
Akihiro Yamamura