Title:
How to treat a pyrimide Diazepi non kinase frame compound and a disease
Document Type and Number:
Japanese Patent JP6125571
Kind Code:
B2
Abstract:
The present invention relates to novel pyrimido-diazepinone compounds, methods of modulating protein kinases, including MPS1 (TTK), ERK5 (BMK1, MAPK7), polo kinase 1,2,3, or 4, Ackl, Ack2, Abl, DCAMKL1, ABL1, Abl mutants, DCAMKL2, ARK5, BRK, MKNK2, FGFR4, TNK1, PLK1, ULK2, PLK4, PRKD1, PRKD2, PRKD3, ROS1, RPS6KA6, TAOK1, TAOK3, TNK2, Bcr-Abl, GAK, cSrc, TPR-Met, Tie2, MET, FGFR3, Aurora, Axl, Bmx, BTK, c-kit, CHK2, Flt3, MST2, p70S6K, PDGFR, PKB, PKC, Raf, ROCK-H, Rskl, SGK, TrkA, TrkB and TrkC, and the use of such compounds in the treatment of various diseases, disorders or conditions.
Inventors:
Nathaniel S. Gray
Cien Min Dong
Nicholas Paul Kwitekowski
Cien Min Dong
Nicholas Paul Kwitekowski
Application Number:
JP2015134522A
Publication Date:
May 10, 2017
Filing Date:
July 03, 2015
Export Citation:
Assignee:
Dana Faber Cancer Institute Incorporated
International Classes:
C07D487/04; A61K31/5513; A61P35/00; A61P43/00
Domestic Patent References:
| JP5908728B2 |
Foreign References:
| WO2008003958A1 | ||||
| WO2007095188A1 | ||||
| WO2008113711A1 | ||||
| WO2009067547A1 | ||||
| WO2007079826A1 | ||||
| WO2004076454A1 | ||||
| WO1999061444A1 |
Attorney, Agent or Firm:
Takuro Saeki
Nakamura Tadashi Exhibition
Naoko Ushiyama
Yuko Saeki
Norio Saeki
Nakamura Tadashi Exhibition
Naoko Ushiyama
Yuko Saeki
Norio Saeki