Title:
全身性エリテマトーデスの治療方法
Document Type and Number:
Japanese Patent JP2010512313
Kind Code:
A
Abstract:
A method of monitoring disease progression of a patient receiving treatment with a therapeutic agent that binds to and modulates IFN± activity comprising: obtaining a first IFN±-inducible PD marker expression profile in a first sample from the patient; administering a therapeutic agent that binds to and modulates IFN± activity; obtaining a second IFN±-inducible PD marker expression profile in a second sample from the patient; and comparing the first and the second IFN±-inducible PD marker expression profiles, wherein a variance in the first and the second IFN±-inducible PD marker expression profiles indicates a level of efficacy of the therapeutic agent that binds to and modulates IFN± activity.
Inventors:
White, barbara
Application Number:
JP2009540285A
Publication Date:
April 22, 2010
Filing Date:
December 06, 2007
Export Citation:
Assignee:
Mediemu, LRC
International Classes:
A61K39/395; A61K45/00; A61P17/00; A61P37/02; A61P43/00
Domestic Patent References:
| JP2004533217A | 2004-11-04 |
Foreign References:
| WO2005059106A2 | 2005-06-30 | |||
| WO2006086586A2 | 2006-08-17 |
Other References:
JPN6012053591; Ｍｏｄｅｒｎ Ｐｈｙｓｉｃｉａｎ Ｖｏｌ．２０，Ｎｏ．１, 2000, ｐ．１０５-１０８
JPN6013024354; 医薬ジャーナル Ｖｏｌ．３９，Ｎｏ．１, 2003, ｐ．７３-７９
JPN6013024357; 日病薬誌 Ｖｏｌ．３８，Ｎｏ．８, 2002, ｐ．９６３-９６６
JPN6013024354; 医薬ジャーナル Ｖｏｌ．３９，Ｎｏ．１, 2003, ｐ．７３-７９
JPN6013024357; 日病薬誌 Ｖｏｌ．３８，Ｎｏ．８, 2002, ｐ．９６３-９６６
Attorney, Agent or Firm:
Yusuke Hiraki
Ishii Teiji
Satoshi Fujita
Eiichi Arai
Natsuo Tanaka
Ishii Teiji
Satoshi Fujita
Eiichi Arai
Natsuo Tanaka