Title:
ヒト型CDR移植抗体およびその抗体断片
Document Type and Number:
Japanese Patent JP4052515
Kind Code:
B2
Abstract:
A human CDR-grafted antibody or the antibody fragment thereof which specifically reacts with the extracellular region of human CC chemokine receptor 4 (CCR4) but does not react with a human blood platelet; a human CDR-grafted antibody or the antibody fragment thereof which specifically reacts with the extracellular region of CCR4 and has a cytotoxic activity against a CCR4-expressing cell; and a medicament, a therapeutic agent or a diagnostic agent comprising at least one of the antibodies and the antibody fragments thereof as an active ingredient.
Inventors:
Kenya Shitara
Kazuyasu Nakamura
Hosaka Emi
Akiko Tanaka
Masamichi Koike
Kazuyasu Nakamura
Hosaka Emi
Akiko Tanaka
Masamichi Koike
Application Number:
JP2003523494A
Publication Date:
February 27, 2008
Filing Date:
August 30, 2002
Export Citation:
Assignee:
Kyowa Fermentation Industry Co., Ltd.
International Classes:
B65H31/30; C12N15/09; A61K39/395; A61P11/02; A61P11/06; A61P17/00; A61P29/00; A61P35/00; A61P35/02; A61P37/00; A61P43/00; B65H31/24; B65H31/26; B65H31/36; B65H37/04; C07K14/715; C07K16/28; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/13; C12P21/02; C12P21/08; G01N33/53; G01N33/68
Domestic Patent References:
| JP3926153B2 |
Foreign References:
| WO2000042074A1 | ||||
| WO2000067791A1 |
Other References:
J.Immunol.,2001年 1月 1日,Vol.166,No.1p.103-111
Int.Immunol.,1999年,Vol.11,No.1,p.81-88
Int.Immunol.,1999年,Vol.11,No.1,p.81-88
Attorney, Agent or Firm:
Shohei Oguri
Kiyozumi Yazawa
Furudate Kutanko
Hironori Honda
Toshimitsu Ichikawa
Kiyozumi Yazawa
Furudate Kutanko
Hironori Honda
Toshimitsu Ichikawa