ヒトDNアーゼ変異体 - Genentech, Incorporated

Title:

ヒトDNアーゼ変異体

Document Type and Number:

Japanese Patent JP4549439

Kind Code:

B2

Abstract:

The present invention relates to amino acid sequence variants of human DNase I that have reduced binding affinity for actin. The invention provides nucleic acid sequences encoding such actin-resistant variants, thereby enabling the production of these variants in quantities sufficient for clinical use. The invention also relates to pharmaceutical compositions and therapeutic uses of action-resistant variants of human DNase I.

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Inventors:

Lazarus, Robert A
Stephen, Shark
Ulmer, Jana S

Application Number:

JP52581996A

Publication Date:

September 22, 2010

Filing Date:

February 21, 1996

Export Citation:

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Assignee:

Genentech, Incorporated

International Classes:

C07K14/47; C12N15/09; A61K38/46; A61P11/00; A61P43/00; C12N9/22; C12N15/00; C12N15/55; A61K38/00; C12R1/19; C12R1/91

Other References:

特表平4-502406号公報

Attorney, Agent or Firm:

Masatake Shiga
Takashi Watanabe
Yasuhiko Murayama
Shinya Mitsuhiro

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