Title:
Human PAC1 antibody
Document Type and Number:
Japanese Patent JP6283408
Kind Code:
B2
Abstract:
Antibodies and antigen-binding fragments thereof that bind to human PAC1 are provided. Nucleic acids encoding the antibodies and antigen-binding fragments thereof, vectors, and cells encoding the same are also provided. The antibodies and antigen-binding fragments thereof can inhibit binding of PAC1 to PACAP, and are useful in a number of PAC1 related disorders, including the treatment and/or prevention of headache disorders, including migraine and cluster headache.
Inventors:
Shui, Zen
Hamburger, Agnes Eva
Hamburger, Agnes Eva
Application Number:
JP2016502989A
Publication Date:
February 21, 2018
Filing Date:
March 14, 2014
Export Citation:
Assignee:
Amgen Incorporated
International Classes:
C12N15/09; A61K39/395; A61P25/04; A61P25/06; A61P43/00; C07K16/28; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/08
Foreign References:
| WO2008018472A1 |
Other References:
Rebecca J. Hermann, et al.,Characterization and use of a rabbit-anti-mouse VPAC1 antibody by flow cytometry.,Journal of Immunological Methods,2012年,Vol.376,p.20-31
C.MORETTI,PACAP and Type I PACAP Receptors in Human Prostate Cancer Tissue,ANNALS OF THE NEW YORK ACADEMY OF SCIENCES,2006年,Vol.1070,p.440-449
ZVIRBLIENE AURELIJA ET AL,Production and characterization of monoclonal antibodies to pituitary adenylate cyclase activating polypeptide type I receptor,HYBRIDOMA,1999年,vol. 18,p.335-342
SCHYTZ H W ET AL,The PACAP Receptor: A Novel Target for Migraine Treatment,NEUROTHERAPEUTICS,2010年,vol. 7,p.191-196
H. W. SCHYTZ, et al.,PACAP38 induces migraine-like attacks in patients with migrane without aura,BRAIN,2008年,Vol.132,p.16-25
C.MORETTI,PACAP and Type I PACAP Receptors in Human Prostate Cancer Tissue,ANNALS OF THE NEW YORK ACADEMY OF SCIENCES,2006年,Vol.1070,p.440-449
ZVIRBLIENE AURELIJA ET AL,Production and characterization of monoclonal antibodies to pituitary adenylate cyclase activating polypeptide type I receptor,HYBRIDOMA,1999年,vol. 18,p.335-342
SCHYTZ H W ET AL,The PACAP Receptor: A Novel Target for Migraine Treatment,NEUROTHERAPEUTICS,2010年,vol. 7,p.191-196
H. W. SCHYTZ, et al.,PACAP38 induces migraine-like attacks in patients with migrane without aura,BRAIN,2008年,Vol.132,p.16-25
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Natsuki Morishita