Title:
ヒト抗ＡＡＶ２カプシドポリクローナル抗体エピトープ
Document Type and Number:
Japanese Patent JP2021523702
Kind Code:
A
Abstract:
中和抗体のエピトープを含むヒト抗ＡＡＶカプシドポリクローナル抗体立体構造エピトープが提供される。このエピトープは、ヒト抗ＡＡＶ２又は他のＡＡＶ株由来カプシドポリクローナル抗体によって認識できる。エピトープのうちの１つ以上を変異させて、抗体中和を回避できるＡＡＶ２及び他のＡＡＶ株由来カプシドを形成してもよい。ヒト抗ＡＡＶカプシドポリクローナル抗体立体構造エピトープを同定する方法も提供される。【選択図】図１Ａ
Inventors:
Kei Adachi
Chan, Xiao, Ran
Hiroyuki Nakai
Chan, Xiao, Ran
Hiroyuki Nakai
Application Number:
JP2020561751A
Publication Date:
September 09, 2021
Filing Date:
May 06, 2019
Export Citation:
Assignee:
Oregon Health and Science University
International Classes:
C12N15/35; A61K35/761; A61K39/39; A61K48/00; A61P37/04; C07K14/015; C07K16/08; C12N7/01; C12N15/10; C12N15/13; C12N15/63; C12N15/864; C12Q1/6869
Domestic Patent References:
| JP2015519895A | 2015-07-16 |
Foreign References:
| US20170067908A1 | 2017-03-09 | |||
| WO2017058892A2 | 2017-04-06 | |||
| WO2017197355A2 | 2017-11-16 |
Other References:
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NATURE COMMUNICATIONS, vol. Vol.5:3075, JPN6023019752, 2014, pages 1 - 14, ISSN: 0005060789
MOLECULAR THERAPY, vol. 22, no. 11, JPN6023019753, 2014, pages 1900 - 1909, ISSN: 0005060790
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PLOS ONE, vol. 8, no. 3, JPN6023019755, 2013, pages 59142 - 1, ISSN: 0005060792
NATURE BIOTECHNOLOGY, vol. 24, no. 2, JPN6023019750, 2006, pages 198 - 204, ISSN: 0005060793
Attorney, Agent or Firm:
Hiraki International Patent Office