Title:
ガングリオシドGM2に対するヒト型相補性決定領域(CDR)移植抗体
Document Type and Number:
Japanese Patent JP4550947
Kind Code:
B2
Abstract:
A human CDR-grafted antibody which specifically reacts with ganglioside GM2, wherein said antibody comprises CDR 1, CDR 2 and CDR 3 of heavy chain (H chain) variable region (V region) comprising amino acid sequences described in SEQ ID NO:1, SEQ ID NO:2 and SEQ ID NO:3, and CDR 1, CDR 2 and CDR 3 of light chain (L chain) V region comprising amino acid sequences described in SEQ ID NO:4, SEQ ID NO: 5 and SEQ ID NO:6, and wherein at least one of the frameworks (FR) of said H chain and L chain V regions comprises an amino acid sequence selected from common sequences (HMHCS; human most homologous consensus sequence) derived from human antibody subgroups.
Inventors:
Kazuyasu Nakamura
Cheno Hanai
Cheno Hanai
Application Number:
JP6698197A
Publication Date:
September 22, 2010
Filing Date:
March 19, 1997
Export Citation:
Assignee:
Kyowa Hakko Kirin Co., Ltd.
International Classes:
C07K16/18; G01N33/53; A61K39/395; A61P35/00; C07K16/30; C12N5/00; C12N5/10; C12N15/09; C12N15/13; C12P21/08; G01N33/531; G01N33/574; G01N33/577; G01N33/92; A61K38/00; C12R1/91
Domestic Patent References:
| JP4502408A | ||||
| JP6205694A | ||||
| JP8503468A |