Title:
HUMAN INTERLEUKIN-6 RECEPTOR-DEVELOPING INHIBITOR
Document Type and Number:
Japanese Patent JP3868021
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To obtain an expression inhibitor against human interleukin-6 receptor (HIL-6R) which contains antisense oligonucleotide derivative and is useful as an HIL-6R inhibitory agent.
SOLUTION: This inhibitor contains, as an active ingredient, an antisense oligonucleotide derivative which hybridize in the region having at least 9, preferably 12-25 base sequence (for example, AGCCTCCTTCCCATGCCAGC), containing the base sequence of the part forming the loop structure of mRNA coding HIL-6R. This derivative acts on the cells producing HIL-6R to bond to the DNA or mRNA coding HIL-6R to inhibit the transcription and translation and inhibit the expression of HIL-6R. The actions of this derivative are, increase in blood platelets, enhancement of antibody production, protein induction in the acute stage, proliferation of tumor cells and differentiation of nerve cells and the like. The dose is 0.1-100mg/kg, preferably 0.1-50mg/kg.
Inventors:
Black circle
Yasuo Koishiwara
Yasuo Koishiwara
Application Number:
JP32313095A
Publication Date:
January 17, 2007
Filing Date:
December 12, 1995
Export Citation:
Assignee:
Chugai Pharmaceutical Co., Ltd.
International Classes:
A61K31/7105; C12N15/09; A61K31/70; A61K48/00; A61P35/00; A61P43/00; C07H21/04; (IPC1-7): A61K31/70; A61K48/00; C07H21/04; //C12N15/09
Domestic Patent References:
| JP8119945A |
Attorney, Agent or Firm:
Takashi Ishida
Fukumoto product
Toshio Toda
Masaya Nishiyama
Fukumoto product
Toshio Toda
Masaya Nishiyama
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