Title:
ヒトモノクローナル抗ＰＤ−Ｌ１抗体および使用方法
Document Type and Number:
Japanese Patent JP6461800
Kind Code:
B2
Abstract:
The present invention comprises human monoclonal antibodies that bind to PD-L1 (also known as programmed death ligand 1 or B7H1). Binding of the invented antibody to PD-L1 inhibits binding to its receptor, PD1 (programmed death 1), and ligand-mediated activities and can be used to treat cancer and chronic viral infections.
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Inventors:
Marasco Wayne A.
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Application Number:
JP2015535829A
Publication Date:
January 30, 2019
Filing Date:
October 04, 2013
Export Citation:
Assignee:
Dana Faber Cancer Institute, Incorporated
International Classes:
C12N15/13; A61K31/713; A61K35/76; A61K38/00; A61K39/395; A61K45/00; A61K48/00; A61K51/00; A61P15/00; A61P31/12; A61P31/18; A61P35/00; C07K16/28; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/63
Domestic Patent References:
| JP2008544755A | ||||
| JP2012503984A |
Other References:
The New England Journal of Medicine,2012年 6月28日,vol. 366, no. 26,p. 2455-2465
The New England Journal of Medicine,2012年 6月28日,vol. 366, no. 26,p. 2443-2454
生物物理,2008年,vol. 48, no. 5,p. 294-298
The New England Journal of Medicine,2012年 6月28日,vol. 366, no. 26,p. 2443-2454
生物物理,2008年,vol. 48, no. 5,p. 294-298
Attorney, Agent or Firm:
Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto
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