Title:
CD25に対するヒトモノクローナル抗体
Document Type and Number:
Japanese Patent JP4966497
Kind Code:
B2
Abstract:
Isolated human monoclonal antibodies which bind to and inhibit human CD25, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced by a hybridoma, a transfectoma or in a nonhuman transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, nonhuman transgenic animals, hybridomas and transfectomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
Inventors:
Suffolman, Janine
Harvenitz, Catalina, Emanuele, Heralda
Palen, Paul
Van de Winkel, Yang, Hae., Yay.
Williams, Denise, Lear
Peter, Petersen
Birdsgon, Ole, Dee., M., ESC
Harvenitz, Catalina, Emanuele, Heralda
Palen, Paul
Van de Winkel, Yang, Hae., Yay.
Williams, Denise, Lear
Peter, Petersen
Birdsgon, Ole, Dee., M., ESC
Application Number:
JP2004553579A
Publication Date:
July 04, 2012
Filing Date:
November 14, 2003
Export Citation:
Assignee:
GENMAB A/S
International Classes:
C12N15/02; A61K39/395; C07K16/28; C07K16/42; C07K16/46; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09; G01N33/53; G01N33/68
Domestic Patent References:
| JP2000502324A | ||||
| JP8140528A | ||||
| JP11004694A | ||||
| JP4316600A |
Foreign References:
| WO2002086085A1 | ||||
| WO2002069232A1 |
Other References:
Proc. Natl. Acad. Sci. U.S.A.,1989年,Vol. 86,pp.10029-10033
J. Immunol. Methods,1999年,Vol. 231,pp.11-23
J. Immunol. Methods,1999年,Vol. 231,pp.11-23
Attorney, Agent or Firm:
Mizuno Yuuki