To provide a hNEU2 inhibitor or a composition showing a chemical chaperone effect on hNEU2.
The human neuraminidase (hNEU2) inhibitor includes: a thiosialooligosaccharide binding dendrimer compound represented by formula (I), a pharmaceutically acceptable salt thereof, or a hydrate of them, and a pharmaceutically acceptable carrier. In the formula: E1 and E2 are any one of carbon, silicon, and germanium and may be same or different mutually; R1 and R2 are same of different hydrocarbon groups; R3, R4 and R5 are same or different hydrocarbon chains which may include oxygen, nitrogen and/or a carbonyl group; Ys are thiosialooligosaccharide residue or other substituents and at least one of Ys is a thiosialooligosaccharide residue; l is an integer of 0-2; m is an integer of 0-2; and k is a number of 0 or 1, and 3-m is 1 when k is 0.
SUZUKI KAORI
ITO KOJI
ITO KOJI
Sumito Sekimoto