HUMANIZED ANTI-β7 ANTAGONIST AND USE THEREFOR

Japanese Patent JP2012107050

A

To provide: anti-beta7 antibodies for treatment; a composition containing these antibodies; and a method for using the same.

This invention relates to methods, compositions, kits and articles of manufacture related to modulating beta7 integrin-mediated pathways, including modulation of MAdCAM-alpha4beta7 binding and leukocyte recruitment to gastrointestinal epithelium, binding and allergy, asthma, IBD (such as Crohn's disease and ulcerative colitis), diabetes, inflammation associated with transplantation, graft versus host disorder and/or allograft disorders and other biological/physiological activities mediated by beta7 integrin.

JP2018526981	Humanized or chimeric CD3 antibody
WO/2023/141600	SILENT ANTI-CD8 ANTIBODIES AND FUSION PROTEINS
JP2012100676	ANTIBODY WITH IMMUNE EFFECTOR ACTIVITY AND THAT INTERNALIZES IN ENDOSIALIN-POSITIVE CELL

DENNIS MARK S
FONG SHERMAN

JP2012037811A

June 07, 2012

February 23, 2012

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GENENTECH INC

C07K16/28; A61K38/00; A61K39/395; A61K45/00; A61P1/04; A61P3/10; A61P11/06; A61P29/00; A61P37/06; A61P43/00

JPH10513365A	1998-12-22
JPH06510671A	1994-12-01

JPN6008006994; Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　（１９９２），　１０，　［７］，　ｐ．７７９-７８３
JPN6008006999; Ｐｒｏｃ．　Ｎａｔｌ．　Ａｃａｄ．　Ｓｃｉ．　ＵＳＡ，　（１９９４），　９１，　［９］，　ｐ．３８０９-３８１３
JPN6008007005; Ｇｅｎｅ，　（１９９６），　１６９，　［２］，　ｐ．１４７-１５５
JPN6008007011; Ｊ．　Ｉｍｍｕｎｏｌ．，　（１９９５），　１５５，　［４］，　ｐ．１９９４-２００４
JPN6008007019; Ｊ．　Ｉｍｍｕｎｏｌ．，　（１９９５），　１５４，　［７］，　ｐ．３３１０-３３１９
JPN6008007084; Ｊ．　Ｍｏｌ．　Ｂｉｏｌ．，　（１９９２），　２２６，　［３］，　ｐ．８８９-８９６

Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita

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