Title:
HUMANIZED ANTI-FACTOR D ANTIBODY
Document Type and Number:
Japanese Patent JP2013027404
Kind Code:
A
Abstract:
To provide anti-Factor D antibodies which are useful for the therapy of complement-mediated disorders.
The invention provides antibodies comprising the heavy and light chain variable domain sequences of murine antibody 166-32, being capable of inhibiting biological activity associated with Factor D. In the other embodiments, the invention provides compositions comprising the antibody, cell lines and vectors harboring the antibody sequences, and a method of making and using the antibodies and compositions. The invention also provides the use of the antibodies for the preparation of a medicament or composition for the treatment of disorders associated with excessive or uncontrolled complement activation.
More Like This:
Inventors:
WU HERREN
SINGH SANJAYA
FUNG SEK CHUNG
AN LING-LING
LOWMAN HENRY B
KELLEY ROBERT F
SINGH SANJAYA
FUNG SEK CHUNG
AN LING-LING
LOWMAN HENRY B
KELLEY ROBERT F
Application Number:
JP2012235325A
Publication Date:
February 07, 2013
Filing Date:
October 25, 2012
Export Citation:
Assignee:
GENENTECH INC
International Classes:
C12N15/09; A61K39/395; A61P27/02; C07K16/40; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/08
Domestic Patent References:
| JP2002503706A | 2002-02-05 |
Other References:
JMB, 1992, 224, PP.487-499, JPN6013015126, ISSN: 0002792650
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Natsuki Morishita