Title:
HUMANIZED ANTIBODIES TO INTERFERON ALPHA RECEPTOR (IFNAR-1)
Document Type and Number:
Japanese Patent JP2011032292
Kind Code:
A
Abstract:
To provide humanized antibodies directed against the IFNAR-1 receptor in which murine CDR sequences have been grafted directly into unmodified human framework sequences, resulting in high affinity, functional antibodies.
The CDRs of the murine anti-human IFNAR-1 monoclonal antibody 64G12 can be grafted onto the FRs of a human antibody sequence to provide humanized antibodies and antibody-derived reagents that have the antigen binding properties of the 64G12 anti-IFNAR-1 mAb and a high antigen binding affinity, while also exhibiting reduced induction of HAMA and augmented effector activities.
Inventors:
CARDARELLI JOSEPHINE M
CHEN TSENG-HUI TIMOTHY
KING DAVID
BEBBINGTON CHRISTOPHER R
POGUE SARAH LEE
CARR FRANCIS J
WILLIAMS STEPHEN
CHEN TSENG-HUI TIMOTHY
KING DAVID
BEBBINGTON CHRISTOPHER R
POGUE SARAH LEE
CARR FRANCIS J
WILLIAMS STEPHEN
Application Number:
JP2010258382A
Publication Date:
February 17, 2011
Filing Date:
November 18, 2010
Export Citation:
Assignee:
MEDAREX INC
International Classes:
C07K16/28; A61K39/395; C07K16/44; C07K16/46; C12N15/09; C07K14/715
Domestic Patent References:
| JP2003503366A | 2003-01-28 | |||
| JPH07505526A | 1995-06-22 |
Foreign References:
| WO2003025019A1 | 2003-03-27 |
Attorney, Agent or Firm:
Masayuki Masabayashi
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