Title:
ベータ－シクロデキストリンを通じたホスト－ゲスト相互作用により感温性ポリホスファゼンに結合した生理活性物質を含むヒドロゲル包接複合体及びその使用
Document Type and Number:
Japanese Patent JP7373702
Kind Code:
B2
Abstract:
Provided is a hydrogel composition including thermosensitive poly(phosphazene) to which a plurality of hydrophobic amino acids, hydrophilic polymers, and host molecules are substituted; and a physiologically active material linked to a guest molecule, wherein the poly(phosphazene) and the physiologically active material form a conjugate by inclusion of the guest molecule in the host molecule via a host-guest interaction.When injected into a living body, the hydrogel composition of the present disclosure slowly releases the physiologically active material and provides favorable conditions for stem cell differentiation. In addition, the hydrogel composition, in which the kind, ratio, and sequence of the physiologically active material are controlled to be suitable for stem cell differentiation, may be prepared with high reproducibility.
Inventors:
Song, Su Chan
Hong, Ki Hyun
Hong, Ki Hyun
Application Number:
JP2021576096A
Publication Date:
November 06, 2023
Filing Date:
May 19, 2020
Export Citation:
Assignee:
Nexgel Biotech Company, Limited
International Classes:
A61L27/52; A61K9/06; A61K35/28; A61K38/08; A61K38/20; A61K47/69; A61L27/20; A61L27/22; A61L27/26; A61L27/54; A61P19/04; A61P35/00; A61P35/04; A61P43/00; C07K5/083; C07K5/097; C07K5/11; C07K5/113; C07K7/06; C07K7/08; C07K14/475; C07K14/48; C07K14/485; C07K14/49; C07K14/495; C07K14/505; C07K14/52; C07K14/53; C07K14/535; C07K14/54; C07K14/55; C07K14/56; C07K14/565; C07K14/57; C07K14/575; C07K14/585; C07K14/59; C07K14/60; C07K14/605; C07K14/61; C07K14/62; C07K14/635; C07K14/65; C07K14/675; C07K14/695; C07K14/70; C07K14/78; C08G79/025; C08K5/00; C08L85/02; C08L101/02
Domestic Patent References:
| JP2004523502A |
Foreign References:
| US20090047348 |
Other References:
ZHANG, J. T. et al,Preparation and Characterization of Novel Temperature Sensitive Poly(N-isopropylacrylamide-co-acryloyl beta-cyclodextrin) Hydrogels with Fast Shrinking Kinetics,Macromol. Chem. Phys.,2004年,Vol.205,pp.107-113
TIAN, Z. et al,Synthesis and Assembly of Novel Poly(organophosphazene) Structures Based on Noncovalent "Host-Guest" Inclusion Complexation,Macromolecules,2014年,Vol.47,pp.1065-1072
TIAN, Z. et al,Synthesis and Assembly of Novel Poly(organophosphazene) Structures Based on Noncovalent "Host-Guest" Inclusion Complexation,Macromolecules,2014年,Vol.47,pp.1065-1072
Attorney, Agent or Firm:
HARAKENZO WORLD PATENT & TRADEMARK