Title:
ガドリニウム系造影剤におけるｔｅｒｔ－ブチルエステルの加水分解方法
Document Type and Number:
Japanese Patent JP7128890
Kind Code:
B2
Abstract:
The present invention provides a hydrolysis method for tert-butyl ester in gadolinium-based contrast agent. The hydrolysis method comprises the step of hydrolyzing the tert-butyl ester with a catalyst. The preparation method of the catalyst comprises the following steps: subjecting zirconia and titanium tetrachloride to reaction in the presence of sulfuric acid and water at 60°C to 90°C until the solid is dissolved, adding silica to perform reaction for 1 to 5 h, filtering to obtain solids, washing and calcining the solid. This hydrolysis method does not introduce other substances which are difficult to remove, such as acids, and provides high hydrolysis efficiency and high purity of the obtained product.
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Inventors:
Zhang, Jihwa
Ryu, Yunlong
Ryu, Yunlong
Application Number:
JP2020529205A
Publication Date:
August 31, 2022
Filing Date:
January 29, 2019
Export Citation:
Assignee:
HUBEI TIANSHU PHARMACEUTICAL CO., LTD
International Classes:
A61K49/06; B01J21/06
Domestic Patent References:
| JP2001314763A |
Foreign References:
| WO2020154892A1 | ||||
| CN103068790A | ||||
| CN104740655A | ||||
| CN101062481A | ||||
| CN1623664A |
Attorney, Agent or Firm:
Ryu Iwatani
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