Title:
親水性ポリマー-マルチカルボキシルオリゴペプチドと薬剤分子との結合生成物、医薬組成物およびその薬学上の使用
Document Type and Number:
Japanese Patent JP4365221
Kind Code:
B2
Abstract:
The present invention relates to a conjugate of hydrophilic polymer-multicarboxyl oligopeptide and drug molecule of the following formula: wherein: P is a water soluble polymer; m is an integer of 2 SIMILAR 12; j is an integer of 1 SIMILAR 6; Ri is a group selected from H, C1-12 alkyl, substituted aryl, aralkyl, heteroalkyl and substituted alkyl; X and Z are linking groups; and TA is drug molecule. The conjugate has low toxicity and an ability to carry more than one drug molecule to improve solubility, sustain and control drug release, and has a remarkably enhancing effect especially to antitumor drug such as paclitaxel and camptothecin etc.
Inventors:
lesson Seyama
Zhu Dee
Zhu Dee
Application Number:
JP2003573050A
Publication Date:
November 18, 2009
Filing Date:
March 05, 2003
Export Citation:
Assignee:
Beijing Key Kai Technology Co., Ltd.
International Classes:
A61K47/48; A61K9/02; A61K9/08; A61K9/10; A61K9/12; A61K9/14; A61K9/20; A61K9/48; C08G81/00
Domestic Patent References:
| JP2000502109A | ||||
| JP5112596A | ||||
| JP4505020A | ||||
| JP4352755A | ||||
| JP11152234A |
Foreign References:
| WO2000050059A1 |
Attorney, Agent or Firm:
Ikeuchi, Sato & Partners