HYDROPHILIC POWDERY THEOPHYLINE MOLDING AND MANUFACTURE THEREOF

Japanese Patent JPH02243630

A

PURPOSE: To obtain the subject molded form for oral use, comprising theophylline, lecithin and a saccharide, and, as the case may be, a fluidizing agent and additive in specified proportions, extraordinarily highly dispersible in water just before taken, and wisely suppressed in the bitter taste of the theophylline. CONSTITUTION: This powdery molded form comprises (A) 5-15 (pref. 8-12)wt.% of theophylline, (B) 15-30 (pref. 20-25)wt.% of lecithin, (C) 45-80 (pref. 55-70)wt.% of a saccharide (pref. sucrose), and, as the case may be, (D) 0-50 (pref. 1-3)wt.% of a fluidizing agent, pref. porous silica gen. and (E) 0-30 (pref. 0.1-5)wt.% of a food color, gustatory ingredient and/or antioxidant. This molded form is obtained by the following process: The component C is dissolved at 70-100 deg.C in an aqueous solution of the component A, and the components B and E are then dispersed or dissolved in the resultant solution, the resultant hot solution is evaporated to dryness. The resultant dry powder is sieved followed by, as the case may be, addition of the component D.

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DEIITOMARU HORUN
GETSU KURIYUGAA
RAINHARUTO SHIYUPENGURAA

JP20493889A

September 27, 1990

August 09, 1989

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BASF AG

A61K9/16; A61K31/52; A61K47/24; A61K9/14; A61K47/26; A61P11/08; (IPC1-7): A61K9/14; A61K31/52; A61K47/24

Tajiro Taiji

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