Title:
レチノールのヒドロキシアルカン酸及びヒドロキシアルカン酸オリゴマーエステル
Document Type and Number:
Japanese Patent JP5960730
Kind Code:
B2
Abstract:
Retinyl hydroxyesters and retinyl oligo-hydroxyesters were prepared using a chemoenzymatic process from retinol and short chain esters of hydroxycarboxylic acids or short chain esters of hydroxycarboxylic acids. The presence of the hydroxyl group on the acid can result in a mixture of esters from various oligomers of the hydroxycarboxylic acid. The retinyl ester products are readily enzymatically hydrolyzed in vitro, which indicates that application to the skin should result in release of the anti-aging ingredient retinol (without the inherent instability and irritation) along with the acid, which, if chosen appropriately, should also have desirable biological effects. This combination should be effective as an anti-aging skin care ingredient.
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Inventors:
Neil Warren Boaz
Application Number:
JP2013554584A
Publication Date:
August 02, 2016
Filing Date:
February 16, 2012
Export Citation:
Assignee:
EASTMAN CHEMICAL COMPANY
International Classes:
C07C403/12; A61K8/67; A61Q19/08; C12P7/62
Domestic Patent References:
| JP2005139176A | ||||
| JP2004517876A | ||||
| JP2012500264A | ||||
| JP9509403A |
Foreign References:
| DE4415204A1 | ||||
| WO1997020812A1 |
Other References:
REGISTRY[STN online],2008年 6月 8日,RN:1026294-10-9
Biotechnology Progress,2002年,18(3),424-428
Enzyme and Microbial Technology,2003年,32,312-320
Journal of Molecular Catalysis B: Enzymatic,2000年,8,275-280
Biotechnology Progress,2002年,18(3),424-428
Enzyme and Microbial Technology,2003年,32,312-320
Journal of Molecular Catalysis B: Enzymatic,2000年,8,275-280
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Tetsuji Koga
Yoichi Watanabe
Masaru Nakajima
Suzuki Keiyasu
Satoshi Deno
Atsushi Ebiya
Takashi Ishida
Tetsuji Koga
Yoichi Watanabe
Masaru Nakajima
Suzuki Keiyasu
Satoshi Deno
Atsushi Ebiya