Title:
ヒドロキシル化三環化合物
Document Type and Number:
Japanese Patent JP2014505034
Kind Code:
A
Abstract:
The invention provides small molecule drugs that are chemically modified by covalent attachment of a water-soluble oligomer. A compound of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the small molecule drug not attached to the water-soluble oligomer.
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Inventors:
Riggs-Sausier, Jennifer
Den, Bo-Liang
Gurusahani, hema
Den, Bo-Liang
Gurusahani, hema
Application Number:
JP2013543386A
Publication Date:
February 27, 2014
Filing Date:
December 09, 2011
Export Citation:
Assignee:
Wells Fargo Bank National Association
International Classes:
C07C217/52; A61K31/137; A61K31/335; A61K31/4523; A61K31/473; A61K31/5415; A61K31/55; A61K31/551; A61K47/48; A61P25/24; C07D219/06; C07D223/22; C07D243/38; C07D279/22; C07D313/12; C07D405/06
Domestic Patent References:
| JP2006519236A | 2006-08-24 |
Foreign References:
| WO2009073154A1 | 2009-06-11 | |||
| CN1496975A | 2004-05-19 | |||
| WO2009073154A1 | 2009-06-11 |
Other References:
JPN5014001840; ＶＥＲＯＮＥＳＥ ＦＲＡＮＣＥＳＣＯ Ｍ: 'ＰＥＧＹＬＡＴＩＯＮ， ＳＵＣＣＥＳＳＦＵＬ ＡＰＰＲＯＡＣＨ ＴＯ ＤＲＵＧ ＤＥＬＩＶＥＲＹ' ＤＲＵＧ ＤＩＳＣＯＶＥＲＹ ＴＯＤＡＹ Ｖ１０ Ｎ２１, 20051101, Ｐ１４５１-１４５８, ＥＬＳＥＶＩＥＲ
JPN7015002096; ＶＥＲＯＮＥＳＥ ＦＲＡＮＣＥＳＣＯ Ｍ: ＢＩＯＤＲＵＧＳ Ｖ．２２， Ｎ．５, 2008, Ｐ．３１５-３２９
JPN6013042974; Ｔｉａｎｂａｏ Ｌｕ ｅｔ ａｌ．: Ｔｈｅ Ｊｏｕｒｎａｌ ｏｆ Ｏｒｇａｎｉｃ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ． ５５， Ｎｏ． ８, 1990, ２２６９-２２７０
JPN5014001840; ＶＥＲＯＮＥＳＥ ＦＲＡＮＣＥＳＣＯ Ｍ: 'ＰＥＧＹＬＡＴＩＯＮ， ＳＵＣＣＥＳＳＦＵＬ ＡＰＰＲＯＡＣＨ ＴＯ ＤＲＵＧ ＤＥＬＩＶＥＲＹ' ＤＲＵＧ ＤＩＳＣＯＶＥＲＹ ＴＯＤＡＹ Ｖ１０ Ｎ２１, 20051101, Ｐ１４５１-１４５８, ＥＬＳＥＶＩＥＲ
JPN7015002096; ＶＥＲＯＮＥＳＥ ＦＲＡＮＣＥＳＣＯ Ｍ: ＢＩＯＤＲＵＧＳ Ｖ．２２， Ｎ．５, 2008, Ｐ．３１５-３２９
JPN7015002096; ＶＥＲＯＮＥＳＥ ＦＲＡＮＣＥＳＣＯ Ｍ: ＢＩＯＤＲＵＧＳ Ｖ．２２， Ｎ．５, 2008, Ｐ．３１５-３２９
JPN6013042974; Ｔｉａｎｂａｏ Ｌｕ ｅｔ ａｌ．: Ｔｈｅ Ｊｏｕｒｎａｌ ｏｆ Ｏｒｇａｎｉｃ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ． ５５， Ｎｏ． ８, 1990, ２２６９-２２７０
JPN5014001840; ＶＥＲＯＮＥＳＥ ＦＲＡＮＣＥＳＣＯ Ｍ: 'ＰＥＧＹＬＡＴＩＯＮ， ＳＵＣＣＥＳＳＦＵＬ ＡＰＰＲＯＡＣＨ ＴＯ ＤＲＵＧ ＤＥＬＩＶＥＲＹ' ＤＲＵＧ ＤＩＳＣＯＶＥＲＹ ＴＯＤＡＹ Ｖ１０ Ｎ２１, 20051101, Ｐ１４５１-１４５８, ＥＬＳＥＶＩＥＲ
JPN7015002096; ＶＥＲＯＮＥＳＥ ＦＲＡＮＣＥＳＣＯ Ｍ: ＢＩＯＤＲＵＧＳ Ｖ．２２， Ｎ．５, 2008, Ｐ．３１５-３２９
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto