Title:
HYDROXYPROPYLCELLULOSE WITH LOW SUBSTITUTION DEGREE, COMPOSITION THEREOF AND ITS PRODUCTION
Document Type and Number:
Japanese Patent JP3212531
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To obtain the subject compound capable of providing excellent collapsibility to a tablet and a granule even in addition of a small amount by specifying a proportion of one-substituted body in anhydrous glucose units in a cellulose substituted with a hydroxypropyl group.
SOLUTION: The objective compound is obtained by regulating the proportion of one-substituted body having only one molecule substituted with a hydroxypropyl group in anhydrous glucose units substituted with the hydroxypropyl groups so as to be ≥80mol% of the whole glucose units containing plural number-substituted body. The compound is obtained by reacting (i) a pulp containing ≤0.07wt.%, preferably 0.05wt.% dichloromethane-soluble portion with (ii) (A) an alkali cellulose obtained by impregnation of sodium hydroxide and (B) 0.2-1.0mol propylene oxide per anhydrous glucose unit of the component A at 40-80°C for 1-5hr, neutralizing the free alkali in the reaction product with an acid, and washing, drying and pulverizing the neutralized reaction product.
Inventors:
Yasuaki Mutoh
Sakae Ohara
Mitsuyoshi Oshima
Sakae Ohara
Mitsuyoshi Oshima
Application Number:
JP6801297A
Publication Date:
September 25, 2001
Filing Date:
March 21, 1997
Export Citation:
Assignee:
Shin-Etsu Chemical Co., Ltd.
International Classes:
C08B11/08; (IPC1-7): C08B11/08
Domestic Patent References:
| JP7324101A |
Attorney, Agent or Firm:
Nao Okuyama (2 outside)
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