Title:
11β-ヒドロキシステロイドデヒドロゲナーゼ1型活性化合物
Document Type and Number:
Japanese Patent JP2009532418
Kind Code:
A
Abstract:
A novel class of compounds of the general formula (I), their use in therapy, pharmaceutical compositions comprising the compounds, as well as their use in the manufacture of medicaments are described. The present compounds modulate the activity of 11β-hydroxy-steroid dehydrogenase type 1 (11βHSD1) and are accordingly useful in the treatment of diseases in which such a modulation is beneficial, e.g. the metabolic syndrome.
Inventors:
Evdorp, Seiren
Henrik Sune, Andersen
Henrik Sune, Andersen
Application Number:
JP2009503537A
Publication Date:
September 10, 2009
Filing Date:
March 27, 2007
Export Citation:
Assignee:
High Point Pharmaceuticals, Limited Liability Company
International Classes:
C07C235/54; A61K31/16; A61K31/19; A61K31/403; A61K31/415; A61K31/4402; A61K31/445; A61K31/4523; A61K31/454; A61K31/47; A61K31/4709; A61K31/55; A61P3/04; A61P3/06; A61P3/10; A61P9/12; A61P37/02; A61P43/00; C07D209/02; C07D211/46; C07D213/64; C07D213/71; C07D215/08; C07D223/12; C07D223/14; C07D231/18; C07D233/84; C07D401/12; C07D401/14; C07D487/08; C07D491/08
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Yoichi Watanabe
Kazuhiro Nakamura
Masaru Nakajima
Takashi Ishida
Fukumoto product
Tetsuji Koga
Yoichi Watanabe
Kazuhiro Nakamura
Masaru Nakajima