催眠性β-カルボリン誘導体、その製造方法とその医薬品としての用途

Japanese Patent JP4333036

B2

The present invention concerns derivatives of general formula I (I' and I''), in which X represents a divalent radical of formula (a) or (b), R1, R2, R3, and R4 represent, independently of each other, a hydrogen atom, a hydroxy radical, a lower alkyl, lower alkoxy, aryloxy, halo or nitro radical or an unsaturated aliphatic chain, lower alkylcarbonyl, lower alkylcarbonyloxy, carboxyl, these groups being optionally substituted. R5 represents a hydrogen atom, a lower alkyl, cycloalkyl, aryl, lower aralkyl, lower alkoxy, a lower alkylcarbonyl, halo(lower)alkylcarbonyl, lower alkyloxycarbonyl, amino, these groups being optionally substituted. R6, R7, R9, R10, R12, R13, R14 and R15 represent, independently of each other, a hydrogen atom, a lower alkyl, a lower cycloakyl, halo(lower)alkyl, perhalo(lower)alkyl, aryl, aralkyl, lower alkoxy, lower cycloalkoxy, mono or polyhaloalkoxy, aryloxy, aralkyloxy, hydroxyalkyl, alkyloxyalkyl, lower alkylthio, lower cycloalkylthio, these groups being optionally substituted. R8 represents a lower alkyl, a lower cycloalkyl, hydroxyalkyl, alkyloxyalkyl, halo(lower)alkyl, perhalo(lower)alkyl, aryl, these groups being optionally substituted. R11 represents an oxygen atom or a sulfur atom optionally substituted.

Fruty Run, Jean-Bernard
Frutiran, Marianne
Jacqui, Jean-Claude
Joant, Mari-Paul
Violo, bruno
Column, Omar

JP2000536716A

September 16, 2009

March 17, 1999

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M A SE F
Laboratoire Bezan Iscovesco

C07D221/18; A61K31/435; C07D455/02; A61K31/437; A61K31/4375; A61P15/18; A61P21/02; A61P25/00; A61P25/04; A61P25/08; A61P25/18; A61P25/20; A61P25/22; A61P25/24; A61P35/00; A61P43/00; C07D221/04; C07D455/03; C07D471/04; C07D471/14; C07D

WO1996008490A1

Shoichi Hirose

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