To obtain a new compound capable of reducing the concentration of an (ultra) low density lipoprotein cholesterol in plasma or serum and useful for treating and preventing hyperlipemia such as atherosclerosis.
This compound is represented by formula I {R1 and R2 are each a straight-chain 1-6C alkyl; R3 is H or OR11 [R11 is H or a (substituted) 1-6C alkyl]; R4 is pyridyl or a (substituted) phenyl; R5, R6 and R8 are each H, a halogen, cyano, etc.; R7 is represented by formula II (R16 is COOH, CH2OH, etc.), etc.; X is NH or O; R9 and R10 are each H or 1-6C alkyl}. The objective compound is prepared by acylating or alkylating a compound represented by formula III at the group X-H according to the standard method or glycosylating or glucuronidating the compound represented by formula III at the group X-H and then eliminating the protecting group, especially hydroxyl group and amino functional group.
ENHSEN ALFONS (DE)
STENGELIN SIEGFRIED (DE)
GLOMBIK HEINER (DE)
