HYPOMYCIN, STRAIN CAPABLE OF PRODUCING HYPOMYCIN, PRODUCTION OF HYPOMYCIN AND REGULATOR FOR ACAT ACTIVITY

Japanese Patent JPH0841064

A

PURPOSE: To obtain a new hypomycin, capable of lowering the level of choles terol in blood and suppressing arteriosclerosis and having regulating actions on the activities of acyl-coenzyme A-cholesterol acyltransferases (ACAT).

CONSTITUTION: The hypomycin of the formula. This hypomycin is obtained by culturing Hypomyces sp. C409 (FERM P-14374) which is a microorganism belonging to the genus Hypomyces at 24-30°C and about the neutral pH under preferably aerobic conditions, accumulating the hypomycin in the resultant cultured product, separating the cultured product into a culture filtrate and a microbial cell by centrifugation, etc., and respectively collecting the hypomycin. The obtained hypomycin has the following physico-chemical properties: molecular formula: C19H19N1O3; molecular weight: 309; specific rotatory power [α]20D= 84.60 (CHCl3, c=0.5); solubility; soluble in MeOH, Et0H, acetonitrile, EtOAc, CHCl3 and benzene and insoluble in water; neutral; white powder, etc.

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SAWADA HARUJI
CHATANI TAKAKO
TEZUKA KENICHI
WATANABE TSUNEICHI
YOKOKURA TERUO

JP18133494A

February 13, 1996

August 02, 1994

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YAKULT HONSHA KK

C12P17/18; A61K31/397; A61K31/40; A61P3/06; A61P9/10; A61P43/00; C07D477/00; C12N1/14; C12R1/645; (IPC1-7): C07D477/00; A61K31/40; C12N1/14; C12P17/18

Miyuki Ariga (3 outside)

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