HYPOXIA INDUCIBLE FACTOR-1 AND METHOD OF USE - JOHNS HOPKINS UNIV SCHOOL OF M

Title:

HYPOXIA INDUCIBLE FACTOR-1 AND METHOD OF USE

Document Type and Number:

Japanese Patent JP2009077729

Kind Code:

A

Abstract:

To provide a method for the purification and characterization of hypoxia-inducible factor 1 (HIF-1).

HIF-1 is composed of subunits HIF-1 and HIF-1. Purified HIF-1 polypeptide, its amino acid sequence and nucleotide sequence are provided. An HIF-1 dimerizing with HIF-1 to produce a nonfunctional HIF-1 complex is provided. An antibody against HIF-1 and a method for the prevention and treatment of hypoxia-related disorders are also provided.

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Inventors:

SEMENZA GREGG L

Application Number:

JP2008284139A

Publication Date:

April 16, 2009

Filing Date:

November 05, 2008

Export Citation:

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Assignee:

JOHNS HOPKINS UNIV SCHOOL OF M

International Classes:

C12N15/09; A61K48/00; A61P7/00; C07K7/06; C07K7/08; C07K14/47; C07K16/18; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/12; C12P21/02; C12Q1/68; G01N33/53; A61K38/00

Domestic Patent References:

JPH11507541A

1999-07-06

Attorney, Agent or Firm:

Yusuke Hiraki
Ishii Teiji
Satoshi Fujita
Natsuo Tanaka

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