Title:
【発明の名称】IL-16拮抗剤
Document Type and Number:
Japanese Patent JP2003507011
Kind Code:
A
Abstract:
The present invention has found that a series of peptides having sequences that substantially correspond to specific regions of the C-terminus of IL-16 can inhibit the activity of IL-16. The present invention has demonstrated that such IL-16-inhibiting peptides can be as short as 4 amino acid in length. Based on these discoveries, the present invention provides IL-16 antagonist peptides and the use thereof for the treatment of IL-16 mediated disorders such as certain inflammatory diseases.
Inventors:
Center, David M.
Kryukshank, William W..
Kornfeld, Hardy
Kryukshank, William W..
Kornfeld, Hardy
Application Number:
JP2001515701A
Publication Date:
February 25, 2003
Filing Date:
August 04, 2000
Export Citation:
Assignee:
Research Corporation Technologies, Incorporated
International Classes:
A61K31/56; A61K38/00; A61K39/395; A61P1/04; A61P5/14; A61P11/06; A61P25/00; A61P29/00; A61P31/22; C07K5/10; C07K5/11; C07K7/06; C07K7/08; C07K14/54; C07K16/44; C12N15/09; (IPC1-7): C12N15/09; A61K31/56; A61K38/00; A61K39/395; A61P1/04; A61P5/14; A61P11/06; A61P25/00; A61P29/00; A61P31/22; C07K5/10; C07K5/11; C07K7/06; C07K7/08; C07K16/44
Domestic Patent References:
| JP2002500889A | 2002-01-15 | |||
| JPH08510907A | 1996-11-19 | |||
| JP2002500889A | 2002-01-15 | |||
| JPH08510907A | 1996-11-19 |
Foreign References:
| WO1997034620A1 | 1997-09-25 | |||
| WO1997034620A1 | 1997-09-25 |
Other References:
JPN6010031225, Ｊ． Ｉｍｍｕｎｏｌ．, 1998, Ｖｏｌ． １６０, ｐｐ．５９４５−５９５４
JPN6010031227, Ｉｍｍｕｎｏｇｅｎｅｔｉｃｓ, 1998, Ｖｏｌ． ４７, ｐｐ．３９０−３９７
JPN6010031227, Ｉｍｍｕｎｏｇｅｎｅｔｉｃｓ, 1998, Ｖｏｌ． ４７, ｐｐ．３９０−３９７
Attorney, Agent or Firm:
Hidekazu Miyoshi (1 outside)