Title:
【発明の名称】1-(芳香族またはヘテロ芳香族置換)-3-(ヘテロ芳香族置換)-1,3-プロパンジオン類およびそれの使用
Document Type and Number:
Japanese Patent JP2003503386
Kind Code:
A
Abstract:
Certain 1-(aromatic- or heteroaromatic-substituted-3-(heteroaromatic substituted)-1,3-propanediones are described as inhibitors of HIV integrase and inhibitors of HIV replication. These compounds are useful in the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.
Inventors:
Pine, Linda Es
Trang, Lee Can Oh
Chiyuan, Rinhan H
Young, Stephen Day
Egbertson, Melitsa S
Way, Ji Jong S
Emblem, mark d'Abri
Fisher, Sauce Ten Yi
Gale, The Ames P
Runford, H. Marie
Melamed, Jefrey Wye
Clark, David El
Trang, Lee Can Oh
Chiyuan, Rinhan H
Young, Stephen Day
Egbertson, Melitsa S
Way, Ji Jong S
Emblem, mark d'Abri
Fisher, Sauce Ten Yi
Gale, The Ames P
Runford, H. Marie
Melamed, Jefrey Wye
Clark, David El
Application Number:
JP2001506988A
Publication Date:
January 28, 2003
Filing Date:
June 21, 2000
Export Citation:
Assignee:
Merck End-Campany Inc.
Teyularik Incorporated
Teyularik Incorporated
International Classes:
A61K31/4164; A61K31/4178; A61K31/4196; A61K31/426; A61K31/427; A61K31/4375; A61K31/44; A61K31/443; A61K31/4436; A61K31/4439; A61K31/444; A61K31/454; A61K31/4545; A61K31/496; A61K31/4965; A61K31/497; A61K31/505; A61K31/506; A61K31/52; A61K31/522; A61K31/5377; A61K31/538; A61K31/541; A61P31/18; A61P43/00; C07D213/30; C07D213/50; C07D213/61; C07D213/64; C07D213/643; C07D213/65; C07D213/68; C07D213/74; C07D233/54; C07D233/64; C07D239/26; C07D241/12; C07D249/08; C07D249/12; C07D277/20; C07D277/24; C07D401/06; C07D401/10; C07D401/12; C07D401/14; C07D403/06; C07D403/10; C07D403/14; C07D405/04; C07D409/06; C07D409/10; C07D413/06; C07D417/06; C07D417/10; C07D417/14; C07D471/04; C07D473/00; C07D473/04; C07D473/08; C07D473/10; C07D473/34; C07D498/06; C07D521/00; (IPC1-7): C07D213/50; A61K31/4164; A61K31/4178; A61K31/4196; A61K31/426; A61K31/427; A61K31/4375; A61K31/44; A61K31/443; A61K31/4436; A61K31/4439; A61K31/444; A61K31/454; A61K31/4545; A61K31/496; A61K31/4965; A61K31/497; A61K31/505; A61K31/506; A61K31/52; A61K31/522; A61K31/5377; A61K31/538; A61K31/541; A61P31/18; A61P43/00; C07D213/64; C07D213/65; C07D213/68; C07D233/64; C07D239/26; C07D241/12; C07D249/08; C07D277/20; C07D401/06; C07D401/10; C07D401/14; C07D403/06; C07D403/10; C07D405/04; C07D409/06; C07D409/10; C07D413/06; C07D417/06; C07D417/10; C07D417/14; C07D471/04; C07D473/00; C07D473/08; C07D473/10; C07D473/34
Attorney, Agent or Firm:
Yoshio Kawaguchi (5 outside)