Title:
【発明の名称】1,3―オキサチオランヌクレオシド類似体
Document Type and Number:
Japanese Patent JP2927546
Kind Code:
B2
Abstract:
(-)-Cis-4-amino-1- (2-hydroxymethyl-1,3 -oxathiolan-5-yl)-(1H)- pyrimidin-2-one (I) and its derivs. are new. (I) contg. max. 5 wt% of (+)-enantiomer (pref. below 1 wt%) is also claimed. (I) is prepd. by sepn. from a racemic mixt., preferably by chiral HPLC. The stationary phase used is preferably beta-cyclodextrin or cellulose triacetate. Alternatively sepn. is by enzyme-mediated enantioselective catabolism, preferably using an immobilised enzyme. The enzyme is preferably cytidine deaminase or a 5-nucleotidase.
Inventors:
KOOTESU JONASAN ARAN BIKUTAA
MATON IAN MAATEIN
PEN CHAARUZU RICHAADO
SUTOORAA RICHAADO
UIRIAMUSON KURISUTOFUAA
MATON IAN MAATEIN
PEN CHAARUZU RICHAADO
SUTOORAA RICHAADO
UIRIAMUSON KURISUTOFUAA
Application Number:
JP50851391A
Publication Date:
July 28, 1999
Filing Date:
May 02, 1991
Export Citation:
Assignee:
BAIOKEMU FUAAMA INC
International Classes:
A61K31/00; A61K31/505; A61K31/506; A61K31/51; A61K31/513; C07D411/04; A61K31/7072; A61K31/7076; A61K45/06; A61P31/00; A61P31/12; A61P31/18; A61P37/04; C07B57/00; C12P41/00; (IPC1-7): A61K31/505; A61K31/00; C07B57/00; C07D411/04; C12P41/00
Domestic Patent References:
| JP37282A | ||||
| JP5505794A |
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)