Title:
【発明の名称】IL-5インヒビターとしての6-アザウラシル誘導体
Document Type and Number:
Japanese Patent JP2002508001
Kind Code:
A
Abstract:
The present invention is concerned with the use of compounds of formula the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein p represents 0, 1, 2 or 3; q represents 0, 1, 2, 3 or 4; R1 represents hydrogen, C1-6alkyl, mono- or di(C1-6alkyl)aminoC1-6alkyloxy, mercapto, C1-6alkylthio, C3-7cycloalkyl, aryl or C1-6alkyl substituted with mono- or di(C1-6alkyl)amino, C1-6alkyloxy, aryl or Het; R2 represents cyano or a radical of formula -C(-X)-Y-R5; wherein X represents O or S; Y represents O, S, NR6 or a direct bond; R5 represents hydrogen; C3-7cycloalkyl; aryl or optionally substituted C1-6alkyl; and where Y is a direct bond, R5 may also be halo or Het; R3 and R4 each independently represents halo, haloC1-6alkyl, C1-6alkyl, hydroxy, C1-6alkyloxy, C1-6alkylcarbonyloxy, mercapto, C1-6alkylthio, C1-6alkylsulfonyl, C1-6alkylsulfinyl, haloC1-6alkylsulfonyl, aryl, cyano, nitro, amino, mono- and di(C1-6alkyl)amino or (C1-6alkylcarbonyl)amino; aryl represents phenyl or substituted phenyl; and Het represents an optionally substituted heterocycle; in the manufacture of a medicament useful for treating eosinophil-dependent inflammatory diseases. The invention also relates to novel compounds, their preparation and compositions comprising them.
Inventors:
Freinu, Eddie Jean Edgar
Volks, Gustav Maria
Ban Beauve, Jean-Pierre Franc
Dales, Gaston Stanislas Marcella
Volks, Gustav Maria
Ban Beauve, Jean-Pierre Franc
Dales, Gaston Stanislas Marcella
Application Number:
JP50812799A
Publication Date:
March 12, 2002
Filing Date:
July 02, 1998
Export Citation:
Assignee:
JANSSEN PHARMACEUTICA NAAMLOZE VENNOOTSCHAP
International Classes:
A61K31/53; A61K51/00; A61K51/04; A61P11/06; A61P17/00; A61P27/02; A61P27/14; A61P37/08; A61P43/00; C07D253/075; C07D403/10; C07D253/06; C07D417/10; (IPC1-7): C07D253/06; A61K31/53; A61K51/00; A61P11/06; A61P17/00; A61P27/02; A61P27/14; A61P37/08; A61P43/00; C07D403/10; C07D417/10
Attorney, Agent or Firm:
Heiyoshi Odashima (1 person outside)