Title:
【発明の名称】ピルビン酸デヒドロゲナーゼの阻害剤としてのアミド
Document Type and Number:
Japanese Patent JP2003508509
Kind Code:
A
Abstract:
A compound of formula (I):wherein:Ring A is a nitrogen linked mono or bicyclic heterocyclic ring as defined within;R<1 >and R<2 >are independently C1-3alkyl optionally substituted by fluoro or chloro;or R<1 >and R<2 >together with the carbon atom to which they are attached, form a C3-5cycloalkyl ring optionally substituted by fluoro;R<3 >is defined within; andn is 0-5; wherein the values of R<3 >may be the same or different;or a pharmaceutically acceptable salt or an in vivo hydrolysable ester thereof is described. The use of compounds of formula (I) in the production of an elevation of PDH activity in a warm-blooded animal such as a human being are also described. Pharmaceutical compositions, methods and processes for preparation of compounds of formula (I) are detailed.
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Inventors:
Batlin, Roger John
Peace, Janet Elizabeth
Brock, Michael Howard
Nowak, Toasten
Brows, Jeremy Nicholas
Clarke, david stephen
Peace, Janet Elizabeth
Brock, Michael Howard
Nowak, Toasten
Brows, Jeremy Nicholas
Clarke, david stephen
Application Number:
JP2001521689A
Publication Date:
March 04, 2003
Filing Date:
August 30, 2000
Export Citation:
Assignee:
AstraZeneca Activrag
International Classes:
C07D295/18; A61K31/404; A61K31/4468; A61K31/495; A61P3/06; A61P3/10; A61P9/10; C07D209/08; C07D211/32; C07D211/58; C07D241/04; C07D295/185; C07D295/192; C07D295/22; C07D295/26; (IPC1-7): C07D209/08; A61K31/404; A61K31/4468; A61K31/495; A61P3/06; A61P3/10; A61P9/10; C07D211/58; C07D241/04; C07D295/18; C07D295/22
Other References:
JPN6010069629, Ｊ．Ｍｅｄ．Ｃｈｅｍ．，（１９９９），４２（１５），ｐ．２７４１−６
JPN6010069630, Ｂｕｌｌ．Ｓｏｃ．Ｃｈｉｍ．Ｆｒ．，（１９９４），１３１，ｐ．５５５−６０
JPN6010069631, Ｊ．Ｏｒｇ．Ｃｈｅｍ．，６４（７），ｐ．２５７９−８１
JPN6010069632, Ｔｅｔｒａｈｅｄｒｏｎ，（１９６８），２４，ｐ．７−１１
JPN6010069633, Ａｎｇｅｗ．Ｃｈｅｍ．，（１９８１），９３（１），ｐ．１２５−６
JPN6010069634, Ａｎｇｅｗ．Ｃｈｅｍ．，（１９７９），９１（１），ｐ．７２−３
JPN7010003983, Ｂｅｉｌｓｔｅｉｎ Ｏｎｌｉｎｅ，ＢＲＮ＝１２５１８５１
JPN6010069630, Ｂｕｌｌ．Ｓｏｃ．Ｃｈｉｍ．Ｆｒ．，（１９９４），１３１，ｐ．５５５−６０
JPN6010069631, Ｊ．Ｏｒｇ．Ｃｈｅｍ．，６４（７），ｐ．２５７９−８１
JPN6010069632, Ｔｅｔｒａｈｅｄｒｏｎ，（１９６８），２４，ｐ．７−１１
JPN6010069633, Ａｎｇｅｗ．Ｃｈｅｍ．，（１９８１），９３（１），ｐ．１２５−６
JPN6010069634, Ａｎｇｅｗ．Ｃｈｅｍ．，（１９７９），９１（１），ｐ．７２−３
JPN7010003983, Ｂｅｉｌｓｔｅｉｎ Ｏｎｌｉｎｅ，ＢＲＮ＝１２５１８５１
Attorney, Agent or Firm:
Kazuo Shamoto (5 outside)