Title:
【発明の名称】アミノポリカルボン酸およびその誘導体
Document Type and Number:
Japanese Patent JP2833766
Kind Code:
B2
Abstract:
There are provided chelating agents particularly useful for the preparation of diagnostic and therapeutic agents for magnetic resonance imaging, scintigraphy, ultrasound imaging, radiotherapy and heavy metal detoxification, said agents being compound of formula (wherein each X may independently represent a carboxyl group or a derivative thereof or a group R1; each group R1 may independently represent a hydrogen atom, a hydroxylalkyl group, an optionally mono- or polyhydroxylated alkoxy or alkoxyalkyl group; n, m, q, r are each 2, 3 or 4, with the provisos that at least two nitrogens carry a -CHR1X moiety, wherein X is a carboxyl group or a derivative thereof, that each -CHR1X moiety represents other than a methyl group, that at least one -R1 group represents other than hydrogen and that where all but one -CHR1X groups are -CH2COOH, then the remaining -CHR1X group may not represent a hydroxyethyl, 2-hydroxypropyl or 2,3-dihydroxypropyl group) or a salt or metal chelate thereof.
Inventors:
BERUGU ARUNE
ARUMEN TORUSUTEN
KURAAUENESU YOO
RONGUEEDO HOORU
TOOMATSUSEN TERUIE
ARUMEN TORUSUTEN
KURAAUENESU YOO
RONGUEEDO HOORU
TOOMATSUSEN TERUIE
Application Number:
JP50590488A
Publication Date:
December 09, 1998
Filing Date:
July 15, 1988
Export Citation:
Assignee:
NYUKOMEDO AS
International Classes:
A61K47/48; A61K49/04; A61K51/00; A61K51/04; C07C227/18; C07C229/16; C07C229/22; C07C229/76; A61K49/00; C07C237/06; C07D257/02; C07D273/00; C07D285/00; C07F5/00; C07F11/00; C07F15/02; C09K3/00; (IPC1-7): C07C229/16; C07C227/18; C07C229/76; C07D257/02; C07D273/00; C07D285/01; C07D285/15; C09K3/00
Domestic Patent References:
| JP1211573A | ||||
| JP59139390A | ||||
| JP2502820A | ||||
| JP2503910A |
Other References:
【文献】米国特許3364165(US,A)
【文献】米国特許2906762(US,A)
【文献】米国特許2848469(US,A)
【文献】米国特許2831885(US,A)
【文献】米国特許2894023(US,A)
【文献】フランス特許1144585(FR,B)
【文献】J.Chromatogr,第25巻.第2号,第442~446頁(1966)
【文献】Zh,Org.Khim.,第6巻,第8号,第1574~1577頁(1970)
【文献】Chemical Abstracts 104:137019
【文献】Chemical Abstracts 73:98343
【文献】米国特許2906762(US,A)
【文献】米国特許2848469(US,A)
【文献】米国特許2831885(US,A)
【文献】米国特許2894023(US,A)
【文献】フランス特許1144585(FR,B)
【文献】J.Chromatogr,第25巻.第2号,第442~446頁(1966)
【文献】Zh,Org.Khim.,第6巻,第8号,第1574~1577頁(1970)
【文献】Chemical Abstracts 104:137019
【文献】Chemical Abstracts 73:98343
Attorney, Agent or Firm:
Chika Takagi (2 outside)