Title:
【発明の名称】埋込み可能な構造物を製造するための、平滑筋細胞に対する剪断流応力の適用
Document Type and Number:
Japanese Patent JP2002531118
Kind Code:
A
Abstract:
The present invention relates to methods for the growth of smooth muscle cells in culture for the production of tissue-engineered grafts or other implantable replacement structures. More specifically, the invention relates to the application of shear flow stress to smooth muscle cells in culture, wherein the cells align perpendicular to the direction of flow, thus more closely approximating the orientation of the cells in vivo. The resulting cultures and methods are useful for the production of improved vascular grafts, vessels and other implantable structures for the correction of defects or abnormal tissues in the body.
Inventors:
Lee, Anne, A.
Joel Seltinger
Cladakis, Stephanie, M.
Joel Seltinger
Cladakis, Stephanie, M.
Application Number:
JP2000586876A
Publication Date:
September 24, 2002
Filing Date:
December 10, 1999
Export Citation:
Assignee:
Advanced Tissue Sciences, Inc.
International Classes:
A61L27/00; C12N5/071; C12M3/00; A61K35/12; (IPC1-7): C12N5/06; A61L27/00; C12M3/00
Attorney, Agent or Firm:
Yusuke Hiraki (1 person outside)