Title:
【発明の名称】芳香族スルホンヒドロキサム酸のメタロプロテアーゼ阻害剤
Document Type and Number:
Japanese Patent JP2002537378
Kind Code:
A
Abstract:
A treatment process is disclosed that comprises administering an effective amount of an aromatic sulfone hydroxamic acid that exhibits excellent inhibitory activity of one or more matrix metalloprotease (MMP) enzymes, such as MMP-2, MMP-9 and MMP-13, while exhibiting substantially less inhibition at least of MMP-1 to a host having a condition associated with pathological matrix metalloprotease activity. Also disclosed are metalloprotease inhibitor compounds having those selective activities, processes for manufacture of such compounds and pharmaceutical compositions using an inhibitor.
Inventors:
Bata, Thomas Y
Becker, Daniel Pea
Bedel, Louis Jay
Behm, Teri El
Carroll, Jeffrey N
De Cresenzo, Gary A.
Fobien, Ivette M
Frescos, John N
Getman, Daniel Pea
McDonald's, Joseph Jay
Hanson, Gunner Jay
Hookerman, Susan El
Howard, Susan Sea
Colossier, Steve A
Lee, Hui
Deborah A. Misc
Rico, Joseph G
Steer, Nathan W
Trevson, Michael Bee
Bernier, William F
Villa Mill, Clara Eye
Lao, Shashdahar N
Becker, Daniel Pea
Bedel, Louis Jay
Behm, Teri El
Carroll, Jeffrey N
De Cresenzo, Gary A.
Fobien, Ivette M
Frescos, John N
Getman, Daniel Pea
McDonald's, Joseph Jay
Hanson, Gunner Jay
Hookerman, Susan El
Howard, Susan Sea
Colossier, Steve A
Lee, Hui
Deborah A. Misc
Rico, Joseph G
Steer, Nathan W
Trevson, Michael Bee
Bernier, William F
Villa Mill, Clara Eye
Lao, Shashdahar N
Application Number:
JP2000600979A
Publication Date:
November 05, 2002
Filing Date:
February 22, 2000
Export Citation:
Assignee:
G.D.Searl and Company
International Classes:
A61K31/382; A61K31/44; A61K31/445; A61K31/495; A61K31/535; A61K31/54; A61K31/55; A61K31/551; A61K31/553; A61K31/554; C07D211/08; C07D215/38; C07D249/08; C07D401/06; C07D401/14; C07D405/12; C07D405/14; C07D407/12; C07D409/10; C07D409/14; C07D451/02; C07D491/20; (IPC1-7): C07C317/44; A61K31/4545; A61K31/4709; A61K31/4725; A61P1/02; A61P1/04; A61P7/02; A61P9/10; A61P13/02; A61P17/02; A61P19/02; A61P19/08; A61P25/28; A61P27/02; A61P35/04; A61P43/00; C07D211/66; C07D211/94; C07D211/96; C07D239/04; C07D279/06; C07D309/08; C07D309/12; C07D319/06; C07D335/02; C07D401/06; C07D401/12; C07D405/12; C07D405/14; C07D407/12; C07D409/12; C07D409/14; C07D413/14; C07D417/12; C07D455/04; C07D491/113
Attorney, Agent or Firm:
Kazuo Shamoto (5 outside)