Title:
【発明の名称】抗原キャリヤーとしての弱毒化サルモネラSPI2突然変異体
Document Type and Number:
Japanese Patent JP2002524077
Kind Code:
A
Abstract:
The present invention relates to vaccines, in particular, to an attenuated gram-negative cell comprising the SPI2 gene locus, wherein at least one gene of the SPI2 locus is inactivated, wherein said inactivation results in an attenuation/reduction of virulence compared to the wild type of said cell, and to a carrier for the presentation of an antigen to a host, which carrier is said attenuated gram-negative cell, wherein said cell comprises at least one heterologous nucleic acid molecule comprising a nucleic acid sequence coding for said antigen, wherein said cell is capable of expressing said nucleic acid molecule or capable of causing the expression of said nucleic acid molecule in a target cell.
Inventors:
Michael Hansel
Carlos Albert Guzman
Eva medina
Heiko Apfell
Christoph Huck
Carlos Albert Guzman
Eva medina
Heiko Apfell
Christoph Huck
Application Number:
JP2000568983A
Publication Date:
August 06, 2002
Filing Date:
September 03, 1999
Export Citation:
Assignee:
Cleatgen Actien Gezel Shaft
International Classes:
C12N15/09; A61K39/00; A61K39/106; A61K39/112; A61K39/12; A61K39/245; A61K39/29; A61K48/00; A61P31/04; A61P31/12; A61P35/00; C07K14/005; C07K14/195; C07K14/255; C07K14/47; C07K16/12; C07K19/00; C12N1/21; C12N7/00; C12N15/31; C12N15/62; C12N15/63; C12N15/74; C12N15/87; C12R1/01; (IPC1-7): C12N15/09; A61K39/00; A61K39/106; A61K39/112; A61K39/12; A61K39/245; A61K39/29; A61K48/00; A61P31/04; A61P31/12; A61P35/00; C07K14/005; C07K14/195; C07K14/255; C07K14/47; C07K19/00; C12N1/21; C12N7/00
Foreign References:
| WO1996017951A2 | 1996-06-13 |
Attorney, Agent or Firm:
Toshio Yano (4 outside)