Title:
【発明の名称】ベンズアミド誘導体及びサイトカイン阻害剤としてのその使用
Document Type and Number:
Japanese Patent JP2002525358
Kind Code:
A
Abstract:
The invention concerns amide derivatives of formula (I)wherein R3 is (1-6C)alkyl or halogeno; m is 0-3, p is 0-2 and q is 0-4; each of R1 and R2 is a group such as hydroxy, halogeno, trifluoromethyl and cyano; R4 is a basic group such as amino, (1-6C)alkylamino, di-[(1-6C)alkyl]amino, di-[(1-6C)alkyl]amino-(1-6C)alkyl, di-[(1-6C)alkyl]amino-(2-6C)alkoxy, heteroaryl, heteroaryloxy, heteroaryl-(1-6C)alkoxy, heterocyclyl, heterocyclyloxy and heterocyclyl-(1-6C)alkoxy; and Q2 is a group such as heteroaryl, heteroaryloxy or heteroaryl-(1-6C)alkoxy which is optionally substituted; or pharmaceutically-acceptable salts or in-vivo-cleavable esters thereof; processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases or medical conditions mediated by cytokines.
Inventors:
Brown, Diag Sutherland
Brown, George Robert
Brown, George Robert
Application Number:
JP2000572198A
Publication Date:
August 13, 2002
Filing Date:
September 21, 1999
Export Citation:
Assignee:
AstraZeneca Activrag
International Classes:
A61K31/165; A61K31/341; A61K31/381; A61K31/427; A61K31/4406; A61K31/4409; A61K31/4427; A61K31/443; A61K31/4436; A61K31/4439; A61K31/4523; A61K31/4525; A61K31/4545; A61K31/47; A61K31/4709; A61K31/496; A61K31/497; A61K31/5355; A61K31/5377; A61K31/55; A61K31/551; A61P7/00; A61P9/10; A61P9/12; A61P11/00; A61P11/06; A61P17/04; A61P17/06; A61P19/00; A61P19/02; A61P19/06; A61P19/08; A61P29/00; A61P35/00; A61P35/02; A61P37/00; A61P37/08; C07C235/56; C07D213/81; C07D213/82; C07D215/48; C07D231/14; C07D239/42; C07D241/44; C07D249/06; C07D333/40; C07D261/18; C07D271/12; C07D307/68; C07D307/79; C07D307/91; C07D311/58; C07D333/38; C07D333/70; C07D401/04; C07D401/12; C07D403/12; C07D405/12; C07D409/04; C07D413/12; C07D417/04; C07D417/12; (IPC1-7): C07D213/81; A61K31/341; A61K31/381; A61K31/427; A61K31/4406; A61K31/4409; A61K31/4427; A61K31/4436; A61K31/4439; A61K31/4523; A61K31/4525; A61K31/47; A61K31/4709; A61K31/496; A61K31/5355; A61K31/5377; A61K31/55; A61K31/551; A61P7/00; A61P9/10; A61P9/12; A61P11/00; A61P11/06; A61P17/04; A61P17/06; A61P19/00; A61P19/02; A61P19/06; A61P19/08; A61P29/00; A61P35/00; A61P35/02; A61P37/00; A61P37/08; C07D215/48; C07D231/14; C07D261/18; C07D307/68; C07D333/40; C07D401/04; C07D401/12; C07D405/12; C07D417/04; C07D417/12
Attorney, Agent or Firm:
Kazuo Shamoto (5 outside)