Title:
【発明の名称】ベンゾオキサアゼピン及びジオキセピン誘導体、それらの抗腫瘍剤としての用途
Document Type and Number:
Japanese Patent JP3199752
Kind Code:
B2
Abstract:
Compounds of formula (I), (I) wherein R1 and R2 are independently hydrogen, unsubstituted lower alkyl or lower alkyl substituted by lower alkoxy or lower alkyl thio, or acyl which is unsubstituted or substituted by one or more of lower alkyl, lower alkyl substituted by halogen, and lower alkoxy; X is CO or CHOH; Y is CO or CH2; and Z is O or NH, and epimers and enantiomers thereof, or the physiologically usable salts thereof are useful as anti-tumor agents. They can be prepared by fermentation of Aspergillus sp. and, optionally, subsequent modification of functional groups.
Inventors:
Dingla, Urvashi Hoda
Haruyoshi Shirai
Yuki Takehana
Wofclitch, Peter Michael
Nami Yabuki
Haruyoshi Shirai
Yuki Takehana
Wofclitch, Peter Michael
Nami Yabuki
Application Number:
JP50112498A
Publication Date:
August 20, 2001
Filing Date:
May 30, 1997
Export Citation:
Assignee:
Ef Hoffman-La Roche Age
International Classes:
A61K31/00; A61K31/335; A61K31/357; A61K31/55; A61K31/553; A61P35/00; C07D267/20; C07D321/10; C12N1/14; C12P17/08; C12P17/14; C12R1/66; C12R1/68; (IPC1-7): C07D267/20; A61K31/335; A61K31/553; A61P35/00; C07D321/10; C12N1/14; C12P17/08; C12P17/14
Domestic Patent References:
| JP58206520A |
Attorney, Agent or Firm:
Hajime Tsukuni (3 outside)