Title:
【発明の名称】二環式および三環式のヘテロ芳香族化合物
Document Type and Number:
Japanese Patent JP2003513975
Kind Code:
A
Abstract:
Disclosed are compounds of the formula: and the pharmaceutically acceptable salts thereof, wherein W, Q, X, X1, Y and Z are as defined herein. These compounds bind with high selectivity and/or high affinity to the benzodiazepine site of GABAA receptors and are therefore useful in the treatment of central nervous system (CNS) diseases and as probes for the localization of GABAA receptors in tissue samples. Also disclosed are intermediates useful in the preparation of these compounds.
Inventors:
Yuan, Jun
Arbo, Pamela
Show, kenneth
Hutchison, Alan
Arbo, Pamela
Show, kenneth
Hutchison, Alan
Application Number:
JP2001536550A
Publication Date:
April 15, 2003
Filing Date:
November 10, 2000
Export Citation:
Assignee:
Neurogen Corporation
International Classes:
A61K31/437; A61K31/4545; A61K31/496; A61K31/5377; A61K31/541; A61K31/55; A61P25/00; A61P25/20; A61P25/22; A61P25/24; A61P25/28; A61P43/00; C07D217/26; C07D237/30; C07D471/04; C07D487/04; C07D519/00; (IPC1-7): C07D487/04; A61K31/437; A61K31/4545; A61K31/496; A61K31/5377; A61K31/541; A61K31/55; A61P25/20; A61P25/22; A61P25/24; A61P25/28; A61P43/00; C07D519/00
Attorney, Agent or Firm:
Hidekazu Miyoshi (1 outside)