Title:
【発明の名称】増大したバイオアベイラビリティを有する胆汁酸含有プロドラッグ
Document Type and Number:
Japanese Patent JP2003530329
Kind Code:
A
Abstract:
Many compounds have poor bioavailability or variable bioavailability because of poor absorption of the compound in the small intestine. Conjugation of the compound with bile acid to form a prodrug will increase the bioavailibility of the compound and/or reduce the bioavailability variability of the compound because of the active transport of the prodrug by the intestinal bile acid transporter and because of increased lipophilic nature of the prodrug. A linker group can be used between the bile acid and the compound. One example of a bile acid containing prodrug is acyclovir valylchenodeoxycholate, where valine is the linker group. Another example of this prodrug is atenolol cholic acid amide.
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Inventors:
Polly, James E.
Coup, Andrew
Maeda, Dean Wye.
Lenz, Kimberly A.
Coup, Andrew
Maeda, Dean Wye.
Lenz, Kimberly A.
Application Number:
JP2001574050A
Publication Date:
October 14, 2003
Filing Date:
April 06, 2001
Export Citation:
Assignee:
University of Maryland, Baltimore
Polly, James E.
Coup, Andrew
Maeda, Dean Wye.
Lenz, Kimberly A.
Polly, James E.
Coup, Andrew
Maeda, Dean Wye.
Lenz, Kimberly A.
International Classes:
A61K47/48; A61K31/165; A61K31/522; A61K31/575; A61K31/58; A61K35/50; A61K39/395; A61K39/40; A61K39/42; A61K39/44; A61P9/04; A61P31/12; A61P43/00; C07J9/00; C07J41/00; C07J43/00; A61K; (IPC1-7): C07J41/00; A61K31/165; A61K31/522; A61K31/575; A61K31/58; A61P9/04; A61P31/12; A61P43/00
Attorney, Agent or Firm:
Shusaku Yamamoto (2 outside)