Title:
【発明の名称】生分解性および骨形成性を有する移植骨片代用組成体
Document Type and Number:
Japanese Patent JP2820415
Kind Code:
B2
Abstract:
A biodegradable device for facilitating healing of structural voids in bone, cartilage as well as soft tissue, is disclosed in the most preferred form including a porous macrostructure made from a biodegradable polymer and a chemotactic ground substance in the form of an RGD attachment moiety of fibro-nectin formed as a porous microstructure. For repair of articular cartilage, harvested precursor cells are secured to the biodegradable carrier which is shaped for press fitting into the articular cartilage lesion. In the most preferred form, the chemotactic ground substance enhances the attractiveness of the biodegradable device for cellular attachment at the site of repair and also facilitates the attachment of free, precursor cells such as chondrocytes and bone narrow to the biodegradable device. In the most preferred form, biological modifiers such as transforming growth factor B and basic fibroblastic growth factor are incorporated in the biodegradable device to mediate cellular activity and regulate cellular functions.
Inventors:
John H. Brecke
Application Number:
JP17483188A
Publication Date:
November 05, 1998
Filing Date:
July 12, 1988
Export Citation:
Assignee:
TEAM Biomedical Incorporated
International Classes:
A61L27/00; A61F2/28; A61F2/30; A61F2/46; A61L27/36; A61L27/38; A61L27/48; A61L27/54; A61L27/56; A61L27/58; A61F2/00; A61F2/02; A61F2/36; (IPC1-7): A61L27/00
Domestic Patent References:
| JP6327325A | ||||
| JP62500981A |
Attorney, Agent or Firm:
Nobuo Kinutani