Title:
【発明の名称】殺生物性ヘテロ多環状化合物およびそれらの医療における使用
Document Type and Number:
Japanese Patent JPH06503549
Kind Code:
A
Abstract:
Heterotetracyclic aromatic compounds having biocidal activity containing two hetero atoms selected from oxygen, sulphur and nitrogen and that are substituted by an aminoalkanol group of formula ArCH2NHR or a monomethyl or monoethyl ether thereof, the compound of formula (I) including these ethers containing no more than 29 carbon atoms in total, or an ester or a salt thereof; wherein Ar is a fused tetracyclic hetero aromatic ring system of the formula: in which Z is oxygen, sulphur or a group NR<1> wherein R<1> is hydrogen, methyl or ethyl and is a bicyclic aromatic ring system comprising a phenyl ring and a 5-membered ring system which contains one heteroatom Z<1> selected from oxygen, sulphur or a group NR<2> wherein R<2> is hydrogen, methyl or ethyl; the tetracyclic ring system being optionally substituted by one or two substituents; and R contains not more than eight carbon atoms and is a group wherein m is 0 or 1; R<6> is hydrogen or alkyl optionally substituted by hydroxy; R<7> and R<8> are the same or different and each is hydrogen or alkyl; R<9> is hydrogen, methyl or hydroxymethyl; is a five-or six-membered saturated carbocyclic ring; R<1><0>, R<1><1> and R<1><2> are the same or different and each is hydrogen or methyl; R<1><3> is hydrogen, methyl, hydroxy, or hydroxymethyl; R<1><4> is hydrogen, methyl, hydroxy or hydroxymethyl. Processes for preparing the compounds, intermediates in their preparation, pharmaceutical compositions containing them and their use in medicine are also disclosed.
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Inventors:
Bayer, Kenneth, Walter
Application Number:
JP50533190A
Publication Date:
April 21, 1994
Filing Date:
March 20, 1990
Export Citation:
Assignee:
The Welcome Foundation Limited
International Classes:
A61K31/40; A61P31/04; A61P31/12; A61P35/00; C07D487/04; C07D491/04; A61K31/34; C07D491/044; C07D491/048; C07D493/04; C07D495/04; (IPC1-7): C07D487/04; A61K31/34; A61K31/40; C07D491/048; C07D493/04; C07D495/04
Attorney, Agent or Firm:
Akira Asamura (3 outside)