Title:
【発明の名称】CETP阻害剤ポリペプチド、合成ポリペプチドに対する抗体、および抗アテローム性動脈硬化症治療のための予防薬および治療薬
Document Type and Number:
Japanese Patent JPH08502525
Kind Code:
A
Abstract:
A polypeptide and analogues thereof inhibit cholesteryl ester transfer protein (CETP). An anti-atherosclerosis composition comprises an anti-atherosclerosis effective amount of the polypeptide and a pharmaceutically acceptable carrier. An anti-atherosclerosis kit comprises in separate sterile containers at least one unit of the composition containing the polypeptide, one syringe and one needle. An antibody has specificity for the polypeptide of the invention, the baboon CETP 4kD polypeptide inhibitor, the 1-36 amino acid N-terminal fragment of apo C-I, modified apo A-I (MW:31kD) or modified apo E (MW:41kD). A method of preventing atherosclerosis in a mammal being predisposed to that condition comprises administering to the mammal a prophylactically effective amount of the polypeptide of the invention, and a method of treating a mammal afflicted with atherosclerosis comprises the administration of a therapeutically effective amount of the polypeptide disclosed herein.
Inventors:
Kushwaha, Ramplatap S
McGill, Henry Sea, Jr.
Kanda, Patrick
McGill, Henry Sea, Jr.
Kanda, Patrick
Application Number:
JP50646495A
Publication Date:
March 19, 1996
Filing Date:
August 02, 1994
Export Citation:
Assignee:
Southwest Foundation for Biomedical Research
International Classes:
A61K38/00; A61K39/395; A61P9/10; C07K14/47; C07K16/18; (IPC1-7): C07K14/47; A61K38/00; C07K16/18
Attorney, Agent or Firm:
Kyozo Yuasa (6 people outside)