Title:
【発明の名称】カルバペネム抗菌組成物および治療方法
Document Type and Number:
Japanese Patent JP2002525275
Kind Code:
A
Abstract:
The present invention relates to novel 2-(naphthosultamyl)methyl-carbapenem antibacterial agents or pharmaceutically acceptable salts thereof in combination with other beta -lactams, which are useful in treating and preventing enterococcal infections. The combinations have anti-PBP5 activity as well as activity against the critical PBPs of sensitive isolates. The antibacterial compositions of the present invention thus comprise an important contribution to therapy for treating infections caused by these difficult to control pathogens. This combination is also useful against gram positive microorganisms, especially methicillin resistant Staphylococcus aureus (MRSA), methicillin resistant Staphylococcus epidermidis (MRSE), and methicillin resistant coagulase negative Staphylococci (MRCNS).
Inventors:
Karen El, Dorso
Gil, Jills Jay
Jacques JC Jay
Caller, Joyce
Silver, Lin El
Gil, Jills Jay
Jacques JC Jay
Caller, Joyce
Silver, Lin El
Application Number:
JP2000571020A
Publication Date:
August 13, 2002
Filing Date:
August 31, 1999
Export Citation:
Assignee:
Merck End-Campany Inc.
International Classes:
C07D477/00; A61K31/164; A61K31/397; A61K31/429; A61K31/437; A61K31/47; A61K31/545; A61K31/7052; A61K31/726; A61K45/06; A61P31/04; (IPC1-7): C07D477/00; A61K31/164; A61K31/429; A61K31/437; A61K31/47; A61K31/545; A61K31/7052; A61K31/726; A61P31/04
Attorney, Agent or Firm:
Yoshio Kawaguchi (2 outside)