Title:
【発明の名称】治療用分子の細胞内送達のためのカチオン性両親媒性組成物
Document Type and Number:
Japanese Patent JP2000515138
Kind Code:
A
Abstract:
Novel cationic amphiphiles are provided that facilitate transport of biologically active (therapeutic) molecules into cells. By this invention, such cationic amphiphile is used in a state in which it is capable of accepting additional protons, i.e., it is not fully protonated. For purposes of this invention, cationic amphiphiles may be considered to encompass four general categories: (A) T-shaped/steroid-based amphiphiles; (B) T-shaped/non steroid-based amphiphiles; (C) non T-shaped/steroid based amphiphiles and (D) non T-shaped/non steroid-based amphiphiles.
Inventors:
Marshall, John
Harris, David, Jay.
Lee, Edward, Earl.
Siegel, Craig, S.
Eastman, Simon, Jay.
Chang, Chow Doun
Sur, Ronald, Kay.
Chen, Sen, H.
Harris, David, Jay.
Lee, Edward, Earl.
Siegel, Craig, S.
Eastman, Simon, Jay.
Chang, Chow Doun
Sur, Ronald, Kay.
Chen, Sen, H.
Application Number:
JP50623898A
Publication Date:
November 14, 2000
Filing Date:
July 15, 1997
Export Citation:
Assignee:
The Enzyme Corporation
International Classes:
A61K47/48; A61K9/127; A61K31/70; A61K47/28; A61K48/00; C07J41/00; C07J43/00; C12N15/87; C12N15/88; (IPC1-7): A61K47/48
Attorney, Agent or Firm:
Akira Asamura (3 outside)