Title:
【発明の名称】感染性及び炎症性病変の検出及び治療のためのキメラ抗体
Document Type and Number:
Japanese Patent JP2810230
Kind Code:
B2
Abstract:
A chimeric antibody-agent conjugate for targeting foci of leukocyte accretion comprises a recombinant chimera having an antigen-binding hypervariable region which binds specifically to granulocytes, and a constant region of a human immunoglobulin having an Fc portion with high affinity for receptors on human mononuclear lymphoid cells, said chimera being conjugated to at least one diagnostic agent or therapeutic agent. A method for targeting an imaging or therapy agent to an inflammatory or infectious lesion comprises injecting a mammal parenterally with an effective amount for targeting of the above chimeric anti-leukocyte conjugate.
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Inventors:
Goldenberg, David M
Hansen, Hans Jei
Hansen, Hans Jei
Application Number:
JP50268190A
Publication Date:
October 15, 1998
Filing Date:
December 04, 1990
Export Citation:
Assignee:
Immunome Dex, Inc.
International Classes:
A61K39/395; A61K45/00; A61K47/48; A61K49/00; A61K49/16; A61K51/00; A61K51/10; A61P29/00; A61P31/04; (IPC1-7): A61K39/395; A61K51/00
Attorney, Agent or Firm:
Yoshio Kawaguchi (4 outside)