Title:
【発明の名称】マトリックス内に含まれたリガンドの協同的組み合わせ
Document Type and Number:
Japanese Patent JPH10509980
Kind Code:
A
Abstract:
The present invention provides compositions and methods for promoting cell migration and tissue regeneration. The composition contains a ligand for the alpha v beta 3 integrin and a ligand for the insulin receptor, the PDGF receptor, the IL-4 receptor, or the IGF receptor, combined in a matrix. The combination of alpha v beta 3 ligand and growth factor produces an unexpected synergistic effect in enhancing wound healing compared with the effect of each component separately. The present invention also provides a method of wound healing and a method of inducing tissue regeneration by applying the compositions of the present invention to the site of the wound.
More Like This:
Inventors:
Buoli, christina
Luos Larch, Archai.
Luos Larch, Archai.
Application Number:
JP51904396A
Publication Date:
September 29, 1998
Filing Date:
November 30, 1995
Export Citation:
Assignee:
La Jolla Cancer Research Foundation
International Classes:
A61K38/00; A61K38/22; A61K38/28; A61K38/39; A61K47/48; A61L26/00; A61P17/00; C07K7/06; C07K7/08; C07K14/49; C07K14/54; C07K14/62; C07K14/65; C07K14/78; C07K17/02; C07K17/10; C12N5/00; (IPC1-7): C07K7/06; A61K38/00; A61K38/22; A61K38/28; A61K47/48; C07K7/08; C07K14/49; C07K14/54; C07K14/62; C07K14/65; C07K14/78; C07K17/02; C07K17/10
Attorney, Agent or Firm:
Shusaku Yamamoto